DegronMD

Uniprot ID: P49335

Source protein: POU domain, class 3, transcription factor 4

Source gene: POU3F4

Class: DEG_SPOP_SBC_1

Location: 66:70

E3 ligase: SPOP

DEGRON score: 0.5761

ASA_SCORE: 49.68

COIL: 0.761

CONS_SCORE: 0.4427

DSS_SCORE: 0.5098

HELIX: 0.1798

FCONS_SCORE: 0.9894

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q79K	TCGA-86-8279	LUAD	TCGA	PWSST	DEG_SPOP_SBC_1	0.0833
p.Q79K	DO24140	LUAD	ICGC	PWSST	DEG_SPOP_SBC_1	0.0833
p.S68P	TCGA-EJ-5495	PRAD	TCGA	PWSST	DEG_SPOP_SBC_1	0.6752
p.S68P	DO36258	PRAD	ICGC	PWSST	DEG_SPOP_SBC_1	0.6752
p.T59N	DO228667	LICA	ICGC	PWSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49335	POU domain, class 3, transcription factor 4	DEG_SPOP_SBC_1	66:70	PWSST	SPOP	0.5761	More...
Q13505	Metaxin-1	DEG_SPOP_SBC_1	19:23	PWSST	SPOP	0.8991	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1613:1617	PWSST	SPOP	0.9884	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	327:331	PWSST	SPOP	0.9984	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	359:363	PWSST	SPOP	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons