DegronMD

Uniprot ID: Q15032

Source protein: R3H domain-containing protein 1

Source gene: R3HDM1

Class: DEG_SPOP_SBC_1

Location: 359:363

E3 ligase: SPOP

DEGRON score: 0.9986

ASA_SCORE: 79.3

COIL: 0.8832

CONS_SCORE: 0.4999

DSS_SCORE: 0.5219

HELIX: 0.0496

FCONS_SCORE: 1.2633

RIG_SCORE: 0.6326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R370Q	TCGA-3B-A9HT	SARC	TCGA	PWSST	DEG_SPOP_SBC_1	0.1389
p.G363D	DO223732	CESC	ICGC	PWSST	DEG_SPOP_SBC_1	0.7198
p.G363D	DO222755	COCA	ICGC	PWSST	DEG_SPOP_SBC_1	0.7198
p.L365V	DO14228	HNSC	ICGC	PWSST	DEG_SPOP_SBC_1	0.7222
p.S352F	DO23466	LINC	ICGC	PWSST	DEG_SPOP_SBC_1	0.1389
p.T362A	DO41331	UCEC	ICGC	PWSST	DEG_SPOP_SBC_1	0.7139
p.E351K	SIDM01318	Hepatocellular Carcinoma	GDSC	PWSST	DEG_SPOP_SBC_1	0.1111
p.K353N	ACH-000578	Lung Cancer	CCLE	PWSST	DEG_SPOP_SBC_1	0.2778
p.S354A	ACH-001610	Brain Cancer	CCLE	PWSST	DEG_SPOP_SBC_1	0.6389
p.S353G	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PWSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49335	POU domain, class 3, transcription factor 4	DEG_SPOP_SBC_1	66:70	PWSST	SPOP	0.5761	More...
Q13505	Metaxin-1	DEG_SPOP_SBC_1	19:23	PWSST	SPOP	0.8991	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1613:1617	PWSST	SPOP	0.9884	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	327:331	PWSST	SPOP	0.9984	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	359:363	PWSST	SPOP	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons