DegronMD

Uniprot ID: Q9Y2K5

Source protein: R3H domain-containing protein 2

Source gene: R3HDM2

Class: DEG_SPOP_SBC_1

Location: 327:331

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 76.84

COIL: 0.8346

CONS_SCORE: 0.4318

DSS_SCORE: 0.5787

HELIX: 0.0376

FCONS_SCORE: 1.2127

RIG_SCORE: 0.6126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S329N	TCGA-DK-A2I4	BLCA	TCGA	PWSST	DEG_SPOP_SBC_1	0.7069
p.S322Y	TCGA-O2-A52S	LUSC	TCGA	PWSST	DEG_SPOP_SBC_1	0.1944
p.R338W	TCGA-Z2-A8RT	SKCM	TCGA	PWSST	DEG_SPOP_SBC_1	0.1389
p.D317E	DO229035	LICA	ICGC	PWSST	DEG_SPOP_SBC_1	0.0556
p.Q323H	DO23874	LUAD	ICGC	PWSST	DEG_SPOP_SBC_1	0.2222
p.R317S	DO45322	LUAD	ICGC	PWSST	DEG_SPOP_SBC_1	0.0556
p.R317M	DO41999	UCEC	ICGC	PWSST	DEG_SPOP_SBC_1	0.0556
p.M340T	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	PWSST	DEG_SPOP_SBC_1	0.0833
p.M340T	ACH-000220	Lymphoma	CCLE	PWSST	DEG_SPOP_SBC_1	0.0833
p.Q318L	HCC-15	lung	COSMIC	PWSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49335	POU domain, class 3, transcription factor 4	DEG_SPOP_SBC_1	66:70	PWSST	SPOP	0.5761	More...
Q13505	Metaxin-1	DEG_SPOP_SBC_1	19:23	PWSST	SPOP	0.8991	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1613:1617	PWSST	SPOP	0.9884	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	327:331	PWSST	SPOP	0.9984	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	359:363	PWSST	SPOP	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons