DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SPOP_SBC_1

Location: 1555:1559

E3 ligase: SPOP

DEGRON score: 0.989

ASA_SCORE: 71.96

COIL: 0.8278

CONS_SCORE: 0.3503

DSS_SCORE: 0.3735

HELIX: 0.1142

FCONS_SCORE: 0.7819

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1546R	TCGA-AN-A04D	BRCA	TCGA	VHSTS	DEG_SPOP_SBC_1	0.0833
p.A1547S	TCGA-CC-A7IH	LIHC	TCGA	VHSTS	DEG_SPOP_SBC_1	0.1111
p.A1547S	DO52181	LIHC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.1111
p.F1562L	TCGA-EE-A3AH	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	0.25
p.F1562L	DO222635	MELA	ICGC	VHSTS	DEG_SPOP_SBC_1	0.25
p.F1562L	DO37443	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	0.25
p.Y1565H	SIDM00321	Ovarian Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	0.1667
p.Y1565H	TYK-nu	ovary	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.1667
p.S1551C	SIDM01175	Other Sarcomas	GDSC	VHSTS	DEG_SPOP_SBC_1	0.2222
p.S1551C	SW684	soft_tissue	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1660:1664	VHSTS	SPOP	0.9899	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1555:1559	VHSTS	SPOP	0.989	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1788:1792	VHSTS	SPOP	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons