DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 1660:1664

E3 ligase: SPOP

DEGRON score: 0.9899

ASA_SCORE: 88.74

COIL: 0.9184

CONS_SCORE: 0.4486

DSS_SCORE: 0.5619

HELIX: 0.0266

FCONS_SCORE: 0.9299

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1667K	TCGA-29-1694	OV	TCGA	VHSTS	DEG_SPOP_SBC_1	0.25
p.G1668W	TCGA-66-2782	LUSC	TCGA	VHSTS	DEG_SPOP_SBC_1	0.2222
p.G1668W	DO26680	LUSC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.2222
p.Q1652K	TCGA-EE-A2GK	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	0.1111
p.T1656P	TCGA-EO-A22R	UCEC	TCGA	VHSTS	DEG_SPOP_SBC_1	0.2222
p.T1656P	DO42713	UCEC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.2222
p.L1657S	DO222884	COCA	ICGC	VHSTS	DEG_SPOP_SBC_1	0.25
p.T1663I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	0.8189
p.T1663I	SIDM00493	Other Solid Cancers	GDSC	VHSTS	DEG_SPOP_SBC_1	0.8189
p.T1654I	ACH-001367	Neuroblastoma	CCLE	VHSTS	DEG_SPOP_SBC_1	0.2778
p.S1664L	A253	salivary_gland	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.7667
p.S1664L	SKG-IIIa	cervix	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1660:1664	VHSTS	SPOP	0.9899	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1555:1559	VHSTS	SPOP	0.989	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1788:1792	VHSTS	SPOP	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons