DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_SPOP_SBC_1

Location: 1788:1792

E3 ligase: SPOP

DEGRON score: 0.991

ASA_SCORE: 73.46

COIL: 0.8272

CONS_SCORE: 0.6

DSS_SCORE: 0.6622

HELIX: 0.0282

FCONS_SCORE: 1.1

RIG_SCORE: 0.6852

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1787T	TCGA-22-4613	LUSC	TCGA	VHSTS	DEG_SPOP_SBC_1	0.3056
p.I1787T	DO26468	LUSC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.3056
p.S1785R	TCGA-55-6972	LUAD	TCGA	VHSTS	DEG_SPOP_SBC_1	0.25
p.S1785R	DO25010	LUAD	ICGC	VHSTS	DEG_SPOP_SBC_1	0.25
p.D1784V	TCGA-90-7769	LUSC	TCGA	VHSTS	DEG_SPOP_SBC_1	0.2222
p.D1784V	DO26822	LUSC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.2222
p.H1789Q	TCGA-A5-A1OF	UCEC	TCGA	VHSTS	DEG_SPOP_SBC_1	0.647
p.H1789Q	DO42568	UCEC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.647
p.M1801I	TCGA-DA-A960	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	0.0833
p.M1801I	DO219482	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	0.0833
p.P1782R	TCGA-DU-6396	LGG	TCGA	VHSTS	DEG_SPOP_SBC_1	0.1667
p.P1782R	DO22143	LGG	ICGC	VHSTS	DEG_SPOP_SBC_1	0.1667
p.P1794S	TCGA-FR-A726	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	0.2778
p.P1794S	DO48665	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	0.2778
p.R1802K	TCGA-FW-A3R5	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	0.0556
p.R1802K	DO37406	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	0.0556
p.R1802K	SIDM00007	Other Solid Cancers	GDSC	VHSTS	DEG_SPOP_SBC_1	0.0556
p.R1802K	ACH-001550	Skin Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	0.0556
p.R1802K	MCC13	skin	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.0556
p.D1778A	TCGA-L5-A43J	ESCA	TCGA	VHSTS	DEG_SPOP_SBC_1	0.0556
p.T1797I	DO231690	LINC	ICGC	VHSTS	DEG_SPOP_SBC_1	0.1944
p.A1783E	DO50415	PRAD	ICGC	VHSTS	DEG_SPOP_SBC_1	0.1944
p.G1779S	SIDM01295	Pancreatic Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	0.0833
p.R1781H	SIDM00596	Endometrial Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	SIDM00487	Colorectal Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	ACH-000941	Endometrial/Uterine Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	ACH-000954	Endometrial/Uterine Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	ACH-000963	Colon/Colorectal Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	ACH-001517	Endometrial/Uterine Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	ACH-001991	Primary	CCLE	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	CCK-81	large_intestine	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.1389
p.R1781H	HEC-1	endometrium	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.1389
p.D1793A	ACH-000894	Lung Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	0.3056
p.D1793A	NCI-H1869	lung	COSMIC	VHSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1660:1664	VHSTS	SPOP	0.9899	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1555:1559	VHSTS	SPOP	0.989	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1788:1792	VHSTS	SPOP	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHSTS

Degron related mutations and impact score

Drug responses associated with NCKAP5 mutations

All proteins holding degron of VHSTS