DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SPOP_SBC_1

Location: 531:535

E3 ligase: SPOP

DEGRON score: 0.9864

ASA_SCORE: 88.98

COIL: 0.9218

CONS_SCORE: 0.3899

DSS_SCORE: 0.7454

HELIX: 0.0654

FCONS_SCORE: 1.1622

RIG_SCORE: 0.5674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N540K	TCGA-D1-A103	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.1944
p.N540K	DO42312	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.Q541E	TCGA-HQ-A5NE	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	0.1667
p.Q541E	DO51900	BLCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1667
p.H544R	TCGA-QG-A5Z2	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.0833
p.H544R	DO44096	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.0833
p.Q530R	DO230309	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.3056
p.K542N	DO230326	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.25
p.P541L	ACH-002026	Endometrial/Uterine Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons