DegronMD - Q8NFP9(NBEA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1131K	TCGA-AF-A56L	READ	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.0833
p.T1131K	DO50276	READ	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.0833
p.A1860V	TCGA-AP-A1DK	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0556
p.A1860V	DO42033	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0556
p.S1848F	TCGA-AX-A2IO	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation altering degron motif	0.6871
p.E1137D	TCGA-AY-4070	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25
p.E1137D	DO10518	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25
p.S1835I	TCGA-B5-A0JY	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0833
p.S1835I	TCGA-EO-A22X	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0833
p.S1835I	DO43041	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0833
p.S1835I	DO43907	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0833
p.A1133E	TCGA-CM-6676	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.1389
p.A1133E	DO9546	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.1389
p.N1141S	TCGA-D3-A2JF	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.5958
p.N1141S	DO38153	SKCM	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.5958
p.T1839I	TCGA-DF-A2KU	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.1944
p.T1839I	DO223286	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.1944
p.S1143G	TCGA-EO-A22R	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.6993
p.S1143G	DO42713	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.6993
p.D1138Y	TCGA-F5-6814	READ	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.2778
p.D1138Y	DO36556	READ	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.2778
p.D1149H	TCGA-G5-6233	READ	TCGA	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.1944
p.D1149H	DO36626	READ	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.1944
p.S1847C	DO225334	BRCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation altering degron motif	0.643
p.A1133V	DO227786	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.1389
p.M1836V	DO234239	ESAD	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.1111
p.S1845P	DO233787	GACA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation altering degron motif	0.6752
p.E1135K	DO220877	MELA	ICGC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.1944
p.T1840K	DO232045	ORCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.2222
p.S1845F	DO40800	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation altering degron motif	0.7982
p.S1859G	DO52402	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0833
p.S1835C	SIDM02073	Colorectal Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.0833
p.T1840A	SIDM02048	Colorectal Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	1844:1850	Mutation rewiring degron network	0.2222
p.N1141I	SIDM00545	Melanoma	GDSC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.6169
p.N1141I	ACH-000987	Skin Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.6169
p.N1141I	Mewo	skin	COSMIC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.6169
p.L1147I	SIDM00118	Colorectal Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25
p.L1147I	SIDM01611	Endometrial Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25
p.L1147I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25
p.L1147I	ACH-001081	Colon/Colorectal Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25
p.L1147I	HCC2998	large intestine	COSMIC	PNSST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NBEA

UniProt ID: Q8NFP9

Entrez ID: 26960

Protein name: Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NBEA in