DegronMD

Uniprot ID: Q8NFP9

Source protein: Neurobeachin

Source gene: NBEA

Class: DEG_SCF_TRCP1_1

Location: 1844:1850

E3 ligase: BTRC

DEGRON score: 0.9964

ASA_SCORE: 73.1143

COIL: 0.9336

CONS_SCORE: 0.2867

DSS_SCORE: 0.4814

HELIX: 0.0401

FCONS_SCORE: 1.0209

RIG_SCORE: 0.5743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1860V	TCGA-AP-A1DK	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.0556
p.A1860V	DO42033	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.0556
p.S1848F	TCGA-AX-A2IO	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.6871
p.S1835I	TCGA-B5-A0JY	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.0833
p.S1835I	TCGA-EO-A22X	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.0833
p.S1835I	DO43041	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.0833
p.S1835I	DO43907	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.0833
p.T1839I	TCGA-DF-A2KU	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.1944
p.T1839I	DO223286	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.1944
p.S1847C	DO225334	BRCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.643
p.M1836V	DO234239	ESAD	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.1111
p.S1845P	DO233787	GACA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.6752
p.T1840K	DO232045	ORCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.2222
p.S1845F	DO40800	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.7982
p.S1859G	DO52402	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.0833
p.S1835C	SIDM02073	Colorectal Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	0.0833
p.T1840A	SIDM02048	Colorectal Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SCF_TRCP1_1	495:501	DSGSSSS	BTRC	0.9422	More...
Q8IYD1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	DEG_SCF_TRCP1_1	2:8	DSGSSSS	BTRC	0.8884	More...
Q8NFP9	Neurobeachin	DEG_SCF_TRCP1_1	1844:1850	DSGSSSS	BTRC	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons