DegronMD

Uniprot ID: Q8IYB3

Source protein: Serine/arginine repetitive matrix protein 1

Source gene: SRRM1

Class: DEG_SCF_TRCP1_1

Location: 495:501

E3 ligase: BTRC

DEGRON score: 0.9422

ASA_SCORE: 90.9

COIL: 0.9573

CONS_SCORE: 0.3771

DSS_SCORE: 0.8218

HELIX: 0.033

FCONS_SCORE: 0.9687

RIG_SCORE: 0.4137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D504N	TCGA-43-A56V	LUSC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.25
p.P507L	TCGA-DI-A1BU	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.1667
p.S501P	TCGA-EE-A2GB	SKCM	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.5641
p.S501P	DO222683	MELA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.5641
p.S501P	DO37417	SKCM	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.5641
p.Q491P	TCGA-FI-A2D5	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.2222
p.Q491P	DO41331	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.2222
p.D495Y	TCGA-GN-A264	SKCM	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.7325
p.H511Y	TCGA-W3-AA1V	SKCM	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.0556
p.D499N	DO45535	LUSC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.6932
p.H506Y	DO51276	SKCM	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.1944
p.P502L	DO42023	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.3056
p.R509G	SIDM00286	Neuroblastoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	0.1111
p.R509G	ACH-000136	Neuroblastoma	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	0.1111
p.R509G	CHP-126	autonomic_ganglia	COSMIC	DSGSSSS	DEG_SCF_TRCP1_1	0.1111
p.K508E	ACH-001411	Bladder Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	0.25
p.R504G	CHP-126	autonomic_ganglia	COSMIC	DSGSSSS	DEG_SCF_TRCP1_1	0.25
p.R508G	CHP-126	autonomic_ganglia	COSMIC	DSGSSSS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SCF_TRCP1_1	495:501	DSGSSSS	BTRC	0.9422	More...
Q8IYD1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	DEG_SCF_TRCP1_1	2:8	DSGSSSS	BTRC	0.8884	More...
Q8NFP9	Neurobeachin	DEG_SCF_TRCP1_1	1844:1850	DSGSSSS	BTRC	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons