DegronMD - Q8IYB3(SRRM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T416I	TCGA-33-A4WN	LUSC	TCGA	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation altering degron motif	0.8189
p.T416I	DO219121	LUSC	ICGC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation altering degron motif	0.8189
p.V700I	TCGA-36-2547	OV	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1944
p.D504N	TCGA-43-A56V	LUSC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.25
p.P697L	TCGA-55-7994	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.P697L	ES-2	ovary	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.P785L	TCGA-A5-A2K3	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1389
p.P785L	TCGA-B7-A5TI	STAD	TCGA	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1389
p.P785L	DO3122	BRCA	ICGC	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1389
p.S683L	TCGA-AA-3864	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5556
p.S683L	TCGA-W3-AA1R	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5556
p.K410R	TCGA-AG-A008	READ	TCGA	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation substituting flanking lysine	0.3056
p.I244V	TCGA-AN-A0AK	BRCA	TCGA	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2778
p.I244V	DO1608	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2778
p.S705L	TCGA-B5-A3FC	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5
p.S705L	TCGA-SJ-A6ZI	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5
p.A858T	TCGA-BG-A0MC	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2778
p.V228A	TCGA-CK-4951	COAD	TCGA	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0556
p.V228A	DO10582	COAD	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0556
p.V228A	DO233205	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0556
p.T856A	TCGA-CM-5341	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.825
p.Q692E	TCGA-CN-4723	HNSC	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.5633
p.R689Q	TCGA-D1-A17Q	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.R689Q	DO41903	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.R689Q	SIDM00243	Other Solid Cancers	GDSC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.R689Q	ACH-002288	Embryonal Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.R689Q	NEC8	testis	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2778
p.V863A	TCGA-DD-AACD	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.K788M	TCGA-DF-A2KU	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation substituting flanking lysine	0.3333
p.R800K	TCGA-DG-A2KM	CESC	TCGA	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.25
p.P507L	TCGA-DI-A1BU	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.1667
p.S501P	TCGA-EE-A2GB	SKCM	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation altering degron motif	0.5641
p.S501P	DO222683	MELA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation altering degron motif	0.5641
p.S501P	DO37417	SKCM	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation altering degron motif	0.5641
p.R412W	TCGA-EO-A22R	UCEC	TCGA	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.25
p.P686S	TCGA-F4-6570	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1944
p.R701Q	TCGA-F5-6814	READ	TCGA	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1667
p.R701Q	DO50732	ORCA	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1667
p.R701Q	DO36556	READ	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1667
p.Q491P	TCGA-FI-A2D5	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.2222
p.Q491P	DO41331	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.2222
p.D495Y	TCGA-GN-A264	SKCM	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation altering degron motif	0.7325
p.K788Q	TCGA-IB-7651	PAAD	TCGA	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation substituting flanking lysine	0.3333
p.E861Q	TCGA-MV-A51V	BLCA	TCGA	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1944
p.E861Q	DO474	BLCA	ICGC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1944
p.P796L	TCGA-W3-AA1Q	SKCM	TCGA	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.6471
p.H511Y	TCGA-W3-AA1V	SKCM	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.0556
p.P695S	DO10443	COAD	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.6752
p.T865A	DO10060	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.S692L	DO8490	COAD	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7667
p.S692L	DO51275	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7667
p.T241S	DO234180	ESAD	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7116
p.Q701E	DO14830	HNSC	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1667
p.R233C	DO225399	LAML	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1944
p.R683L	DO228948	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5556
p.A860S	DO229037	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2222
p.D243E	DO229054	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.D499N	DO45535	LUSC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation altering degron motif	0.6932
p.S703F	DO220891	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.D243Y	DO222413	MELA	ICGC	ATSTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.A845V	DO46657	PAAD	ICGC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.K797Q	DO46657	PAAD	ICGC	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.6944
p.P427S	DO229453	SKCA	ICGC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.P407S	DO229491	SKCA	ICGC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1111
p.H506Y	DO51276	SKCM	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.1944
p.P805L	DO219487	SKCM	ICGC	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1111
p.P794L	DO222328	STAD	ICGC	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7582
p.P794L	DO43899	UCEC	ICGC	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7582
p.A682T	DO38202	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.0833
p.P502L	DO42023	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.3056
p.K797M	DO223286	UCEC	ICGC	PTPSPS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.8062
p.R407W	DO42713	UCEC	ICGC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1111
p.R687W	SIDM02041	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.R687W	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.R427H	SIDM01006	Plasma Cell Myeloma	GDSC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.R427H	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.R427H	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.V428I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1111
p.R509G	SIDM00286	Neuroblastoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.1111
p.R509G	ACH-000136	Neuroblastoma	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.1111
p.R509G	CHP-126	autonomic ganglia	COSMIC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.1111
p.A405V	SIDM00847	Rhabdomyosarcoma	GDSC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.A405V	ACH-000169	Sarcoma	CCLE	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.A405V	RD	soft tissue	COSMIC	PTPQQS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.T855I	SIDM00410	Other Blood Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.8189
p.T855I	ACH-002317	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.8189
p.T855I	YT	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.8189
p.P688L	SIDM00861	Ovarian Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.25
p.P688L	ACH-000906	Ovarian Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.25
p.P688L	ES-2	ovary	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.25
p.K508E	ACH-001411	Bladder Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation substituting flanking lysine	0.25
p.R504G	CHP-126	autonomic ganglia	COSMIC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation rewiring degron network	0.25
p.T864I	YT	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1111
p.R688Q	NEC8	testis	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.25
p.S705P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5
p.R698Q	NEC8	testis	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.25
p.P687L	ES-2	ovary	COSMIC	PQTSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.R508G	CHP-126	autonomic ganglia	COSMIC	DSGSSSS	DEG_SCF_TRCP1_1	495:501	Mutation substituting flanking lysine	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRRM1

UniProt ID: Q8IYB3

Entrez ID: 10250

Protein name: Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRRM1 in