DegronMD

Uniprot ID: Q8IYB3

Source protein: Serine/arginine repetitive matrix protein 1

Source gene: SRRM1

Class: DEG_SCF_FBW7_1

Location: 792:797

E3 ligase: FBXW7

DEGRON score: 0.981

ASA_SCORE: 106.1

COIL: 0.9893

CONS_SCORE: 0.3971

DSS_SCORE: 0.8157

HELIX: 0.0045

FCONS_SCORE: 1.0711

RIG_SCORE: 0.4647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P785L	TCGA-A5-A2K3	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.P785L	TCGA-B7-A5TI	STAD	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.P785L	DO3122	BRCA	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.K788M	TCGA-DF-A2KU	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.3333
p.R800K	TCGA-DG-A2KM	CESC	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.25
p.K788Q	TCGA-IB-7651	PAAD	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.3333
p.P796L	TCGA-W3-AA1Q	SKCM	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.6471
p.K797Q	DO46657	PAAD	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.6944
p.P805L	DO219487	SKCM	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.1111
p.P794L	DO222328	STAD	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.7582
p.P794L	DO43899	UCEC	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.7582
p.K797M	DO223286	UCEC	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.8062

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14693	Phosphatidate phosphatase LPIN1	DEG_SCF_FBW7_1	238:243	PTPSPS	FBXW7	0.9915	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SCF_FBW7_1	792:797	PTPSPS	FBXW7	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons