DegronMD

Uniprot ID: Q14693

Source protein: Phosphatidate phosphatase LPIN1

Source gene: LPIN1

Class: DEG_SCF_FBW7_1

Location: 238:243

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 78.55

COIL: 0.9492

CONS_SCORE: 0.266

DSS_SCORE: 0.7322

HELIX: 0.0192

FCONS_SCORE: 0.9901

RIG_SCORE: 0.5073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E234K	TCGA-AP-A0LM	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.2222
p.E234K	TCGA-EO-A22X	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.2222
p.E242K	TCGA-AX-A06F	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.7022
p.L250P	TCGA-DW-7834	KIRP	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.L250F	TCGA-WE-A8K4	SKCM	TCGA	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.G244S	DO19793	KIRC	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.3056
p.P242S	DO229050	LICA	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.5641
p.E235D	DO223923	LIHC	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.25
p.P250S	DO48665	SKCM	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.S252R	DO41331	UCEC	ICGC	PTPSPS	DEG_SCF_FBW7_1	0.5278
p.S237L	SIDM00777	Colorectal Carcinoma	GDSC	PTPSPS	DEG_SCF_FBW7_1	0.3056
p.S237L	NCI-H508	large_intestine	COSMIC	PTPSPS	DEG_SCF_FBW7_1	0.3056
p.S246N	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PTPSPS	DEG_SCF_FBW7_1	0.25
p.S246N	KYSE-70	oesophagus	COSMIC	PTPSPS	DEG_SCF_FBW7_1	0.25
p.D231N	ACH-000445	Brain Cancer	CCLE	PTPSPS	DEG_SCF_FBW7_1	0.1389
p.N234T	ACH-000996	Endometrial/Uterine Cancer	CCLE	PTPSPS	DEG_SCF_FBW7_1	0.2222
p.A228T	ACH-002232	Lymphoma	CCLE	PTPSPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14693	Phosphatidate phosphatase LPIN1	DEG_SCF_FBW7_1	238:243	PTPSPS	FBXW7	0.9915	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SCF_FBW7_1	792:797	PTPSPS	FBXW7	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons