DegronMD - Q14693(LPIN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F137V	TCGA-06-5416	GBM	TCGA	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1944
p.F137V	TCGA-06-5416	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.A460S	TCGA-44-6145	LUAD	TCGA	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1667
p.A460S	TCGA-44-6145	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1944
p.P156S	TCGA-76-4927	GBM	TCGA	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1389
p.P156S	TCGA-76-4927	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.S453Y	TCGA-94-8491	LUSC	TCGA	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation altering degron motif	0.6009
p.S453Y	TCGA-94-8491	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.712
p.T463M	TCGA-A5-A0G1	UCEC	TCGA	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.0833
p.T463M	TCGA-A5-A0G1	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.T463M	TCGA-GM-A5PV	BRCA	TCGA	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.0833
p.T463M	TCGA-GM-A5PV	BRCA	TCGA	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.A153V	TCGA-AA-3864	COAD	TCGA	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation substituting flanking lysine	0.3333
p.A153V	TCGA-AA-3864	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation substituting flanking lysine	0.3611
p.E234K	TCGA-AP-A0LM	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.2222
p.E234K	TCGA-EO-A22X	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.2222
p.E242K	TCGA-AX-A06F	UCEC	TCGA	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation altering degron motif	0.7022
p.P195L	TCGA-BH-A208	BRCA	TCGA	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.V138I	TCGA-BR-8360	STAD	TCGA	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2222
p.V138I	TCGA-BR-8360	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.K210R	TCGA-DD-AAVV	LIHC	TCGA	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.7237
p.L250P	TCGA-DW-7834	KIRP	TCGA	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.1389
p.K202N	TCGA-E6-A1LX	UCEC	TCGA	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.R208M	TCGA-EE-A2A0	SKCM	TCGA	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.8632
p.S275L	TCGA-EK-A2RJ	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.N143H	TCGA-F5-6814	READ	TCGA	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7423
p.Q458K	TCGA-HU-A4GT	STAD	TCGA	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.2222
p.Q458K	TCGA-HU-A4GT	STAD	TCGA	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.D142Y	TCGA-VQ-A8P2	STAD	TCGA	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7325
p.L250F	TCGA-WE-A8K4	SKCM	TCGA	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.1389
p.E284D	TCGA-XR-A8TF	LIHC	TCGA	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6758
p.K217N	TCGA-ZF-AA4V	BLCA	TCGA	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.P146L	DO3293	BRCA	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7582
p.P146L	DO3293	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7582
p.T135M	DO8151	COAD	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation blocking phosphorylation signal	0.5833
p.T145M	DO233908	GACA	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.8534
p.G244S	DO19793	KIRC	ICGC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.3056
p.S143R	DO16308	KIRC	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6316
p.L201P	DO20794	KIRP	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.A465T	DO51014	LAML	ICGC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.S444I	DO229015	LICA	ICGC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.2222
p.S444I	DO229015	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1389
p.P242S	DO229050	LICA	ICGC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation altering degron motif	0.5641
p.Q209L	DO44974	LIHC	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6654
p.E235D	DO223923	LIHC	ICGC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.25
p.E292Q	DO26420	LUSC	ICGC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.P439L	DO26772	LUSC	ICGC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.0833
p.K283N	DO27192	LUSC	ICGC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5806
p.N216S	DO222775	MELA	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.N216S	DO47665	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.P133L	DO222843	MELA	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833
p.P295Q	DO37523	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833
p.S218F	DO37583	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1111
p.P142L	DO37819	SKCM	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6471
p.R159M	DO37439	SKCM	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0556
p.R159M	DO37439	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.E277K	DO50286	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.P207S	DO48665	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6752
p.P250S	DO48665	SKCM	ICGC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.1389
p.L201F	DO51281	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.G446D	DO222372	STAD	ICGC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.2778
p.G446D	DO222372	STAD	ICGC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1944
p.P213R	DO229268	THCA	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.C295R	DO229232	THCA	ICGC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833
p.M290I	DO50076	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.K153N	DO41020	UCEC	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation substituting flanking lysine	0.3333
p.K153N	DO41020	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation substituting flanking lysine	0.3611
p.Q440H	DO41871	UCEC	ICGC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1111
p.P462R	DO42616	UCEC	ICGC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1111
p.P462R	DO42616	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1389
p.A141T	DO42472	UCEC	ICGC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.3056
p.A141T	DO42472	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.D210E	DO41416	UCEC	ICGC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.5647
p.S252R	DO41331	UCEC	ICGC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation blocking phosphorylation signal	0.5278
p.S275P	SIDM02072	Colorectal Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.Q458E	SIDM00994	T-Lymphoblastic Leukemia	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.2222
p.Q458E	SIDM00994	T-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.Q458E	SIDM00856	Other Solid Cancers	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.2222
p.Q458E	SIDM00856	Other Solid Cancers	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.P441A	SIDM00617	Hepatocellular Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00617	Hepatocellular Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00781	Colorectal Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00781	Colorectal Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00057	Neuroblastoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00057	Neuroblastoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00552	Rhabdomyosarcoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00552	Rhabdomyosarcoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00040	Gastric Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00040	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00351	Oral Cavity Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00351	Oral Cavity Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM01682	Gastric Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM01682	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SIDM00780	Colorectal Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SIDM00780	Colorectal Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	HARA	lung	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	HARA	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	TMK-1	stomach	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	TMK-1	stomach	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SNU-C2B	large intestine	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SNU-C2B	large intestine	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	TE-4	oesophagus	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	TE-4	oesophagus	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	JHH-2	liver	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	JHH-2	liver	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	SAS	upper aerodigestive tract	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	SAS	upper aerodigestive tract	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.P441A	KYM-1	soft tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1389
p.P441A	KYM-1	soft tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.S237L	SIDM00777	Colorectal Carcinoma	GDSC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.3056
p.S237L	NCI-H508	large intestine	COSMIC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.3056
p.W285R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.8634
p.E447K	SIDM01093	Cervical Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.3056
p.E447K	SIDM01093	Cervical Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2222
p.E447K	SiHa	cervix	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.3056
p.E447K	SiHa	cervix	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2222
p.P149L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7582
p.P149L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7582
p.P149L	NCI-H2110	lung	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7582
p.P149L	NCI-H2110	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7582
p.T154I	SIDM00242	Osteosarcoma	GDSC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation substituting flanking lysine	0.3056
p.T154I	SIDM00242	Osteosarcoma	GDSC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation substituting flanking lysine	0.3333
p.T154I	NOS-1	bone	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation substituting flanking lysine	0.3056
p.T154I	NOS-1	bone	COSMIC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation substituting flanking lysine	0.3333
p.S246N	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.25
p.S246N	KYSE-70	oesophagus	COSMIC	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.25
p.G133A	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833
p.G133A	Calu-6	lung	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833
p.A454T	SIDM00980	Gastric Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation altering degron motif	0.7139
p.A454T	SIDM00980	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.7139
p.A454T	23132-87	stomach	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation altering degron motif	0.7139
p.A454T	23132-87	stomach	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.7139
p.S134N	ACH-000265	Pancreatic Cancer	CCLE	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation blocking phosphorylation signal	0.5556
p.S134N	KP-4	pancreas	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation blocking phosphorylation signal	0.5556
p.D231N	ACH-000445	Brain Cancer	CCLE	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.1389
p.S197N	ACH-000784	Esophageal Cancer	CCLE	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1111
p.S197N	KYSE-70	oesophagus	COSMIC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1111
p.H156P	ACH-000877	Lymphoma	CCLE	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1389
p.H156P	ACH-000877	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.H156P	ACH-001064	Lymphoma	CCLE	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1389
p.H156P	ACH-001064	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.P145L	ACH-000899	Skin Cancer	CCLE	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7582
p.D159E	ACH-000938	Leukemia	CCLE	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0556
p.D159E	ACH-000938	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.S158G	ACH-000952	Prostate Cancer	CCLE	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833
p.S158G	ACH-000952	Prostate Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.N234T	ACH-000996	Endometrial/Uterine Cancer	CCLE	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.2222
p.G201C	ACH-002017	Eye Cancer	CCLE	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.A228T	ACH-002232	Lymphoma	CCLE	PTPSPS	DEG_SCF_FBW7_1	238:243	Mutation rewiring degron network	0.0556
p.S140N	KP-4	pancreas	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.S140N	KP-4	pancreas	COSMIC	PSSSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.D456G	ASH-3	thyroid	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.2778
p.D456G	ASH-3	thyroid	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.3056
p.L274V	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.P272H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.Q272H	TE-9	oesophagus	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.D462G	ASH-3	thyroid	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.1111
p.D462G	ASH-3	thyroid	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1389
p.S203N	KYSE-70	oesophagus	COSMIC	IPPFQD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.A288V	NCI-H1048	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2778
p.A282V	NCI-H1048	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5825
p.M277R	GCT	soft tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.L280V	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2778
p.V451M	SK-UT-1	soft tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation altering degron motif	0.6097
p.V451M	SK-UT-1	soft tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.7208
p.V457M	SK-UT-1	soft tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	448:454	Mutation rewiring degron network	0.25
p.V457M	SK-UT-1	soft tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LPIN1

UniProt ID: Q14693

Entrez ID: 23175

Protein name: Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LPIN1 in