DegronMD

Uniprot ID: Q14693

Source protein: Phosphatidate phosphatase LPIN1

Source gene: LPIN1

Class: DEG_SCF_FBW7_1

Location: 142:149

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 87.1375

COIL: 0.9295

CONS_SCORE: 0.2579

DSS_SCORE: 0.6472

HELIX: 0.0645

FCONS_SCORE: 1.0643

RIG_SCORE: 0.589

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F137V	TCGA-06-5416	GBM	TCGA	PSETPSSS	DEG_SCF_FBW7_1	0.1944
p.P156S	TCGA-76-4927	GBM	TCGA	PSETPSSS	DEG_SCF_FBW7_1	0.1389
p.A153V	TCGA-AA-3864	COAD	TCGA	PSETPSSS	DEG_SCF_FBW7_1	0.3333
p.V138I	TCGA-BR-8360	STAD	TCGA	PSETPSSS	DEG_SCF_FBW7_1	0.2222
p.N143H	TCGA-F5-6814	READ	TCGA	PSETPSSS	DEG_SCF_FBW7_1	0.7423
p.D142Y	TCGA-VQ-A8P2	STAD	TCGA	PSETPSSS	DEG_SCF_FBW7_1	0.7325
p.P146L	DO3293	BRCA	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.7582
p.T135M	DO8151	COAD	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.5833
p.T145M	DO233908	GACA	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.8534
p.S143R	DO16308	KIRC	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.6316
p.P133L	DO222843	MELA	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.0833
p.P142L	DO37819	SKCM	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.6471
p.R159M	DO37439	SKCM	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.0556
p.K153N	DO41020	UCEC	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.3333
p.A141T	DO42472	UCEC	ICGC	PSETPSSS	DEG_SCF_FBW7_1	0.3056
p.P149L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSETPSSS	DEG_SCF_FBW7_1	0.7582
p.P149L	NCI-H2110	lung	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	0.7582
p.T154I	SIDM00242	Osteosarcoma	GDSC	PSETPSSS	DEG_SCF_FBW7_1	0.3056
p.T154I	NOS-1	bone	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	0.3056
p.G133A	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PSETPSSS	DEG_SCF_FBW7_1	0.0833
p.G133A	Calu-6	lung	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	0.0833
p.S134N	ACH-000265	Pancreatic Cancer	CCLE	PSETPSSS	DEG_SCF_FBW7_1	0.5556
p.S134N	KP-4	pancreas	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	0.5556
p.H156P	ACH-000877	Lymphoma	CCLE	PSETPSSS	DEG_SCF_FBW7_1	0.1389
p.H156P	ACH-001064	Lymphoma	CCLE	PSETPSSS	DEG_SCF_FBW7_1	0.1389
p.P145L	ACH-000899	Skin Cancer	CCLE	PSETPSSS	DEG_SCF_FBW7_1	0.7582
p.D159E	ACH-000938	Leukemia	CCLE	PSETPSSS	DEG_SCF_FBW7_1	0.0556
p.S158G	ACH-000952	Prostate Cancer	CCLE	PSETPSSS	DEG_SCF_FBW7_1	0.0833
p.S140N	KP-4	pancreas	COSMIC	PSETPSSS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSETPSSS

Degron related mutations and impact score

Drug responses associated with LPIN1 mutations

All proteins holding degron of PSETPSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14693	Phosphatidate phosphatase LPIN1	DEG_SCF_FBW7_1	142:149	PSETPSSS	FBXW7	0.9959	More...