DegronMD

Uniprot ID: Q14693

Source protein: Phosphatidate phosphatase LPIN1

Source gene: LPIN1

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9783

ASA_SCORE: 80.8167

COIL: 0.8315

CONS_SCORE: 0.2211

DSS_SCORE: 0.6327

HELIX: 0.1322

FCONS_SCORE: 0.908

RIG_SCORE: 0.717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P195L	TCGA-BH-A208	BRCA	TCGA	IPPFQD	LIG_APCC_ABBA_1	0.0556
p.K210R	TCGA-DD-AAVV	LIHC	TCGA	IPPFQD	LIG_APCC_ABBA_1	0.7237
p.K202N	TCGA-E6-A1LX	UCEC	TCGA	IPPFQD	LIG_APCC_ABBA_1	0.25
p.R208M	TCGA-EE-A2A0	SKCM	TCGA	IPPFQD	LIG_APCC_ABBA_1	0.8632
p.K217N	TCGA-ZF-AA4V	BLCA	TCGA	IPPFQD	LIG_APCC_ABBA_1	0.1389
p.L201P	DO20794	KIRP	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.2222
p.Q209L	DO44974	LIHC	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.6654
p.N216S	DO222775	MELA	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.1667
p.N216S	DO47665	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.1667
p.S218F	DO37583	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.1111
p.P207S	DO48665	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.6752
p.L201F	DO51281	SKCM	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.2222
p.P213R	DO229268	THCA	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.25
p.D210E	DO41416	UCEC	ICGC	IPPFQD	LIG_APCC_ABBA_1	0.5647
p.S197N	ACH-000784	Esophageal Cancer	CCLE	IPPFQD	LIG_APCC_ABBA_1	0.1111
p.S197N	KYSE-70	oesophagus	COSMIC	IPPFQD	LIG_APCC_ABBA_1	0.1111
p.G201C	ACH-002017	Eye Cancer	CCLE	IPPFQD	LIG_APCC_ABBA_1	0.2222
p.S203N	KYSE-70	oesophagus	COSMIC	IPPFQD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14693	Phosphatidate phosphatase LPIN1	LIG_APCC_ABBA_1	205:210	IPPFQD	APC,CDC20,FZR1	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons