DegronMD

Uniprot ID: Q14693

Source protein: Phosphatidate phosphatase LPIN1

Source gene: LPIN1

Class: DEG_SCF_TRCP1_1

Location: 448:454

E3 ligase: BTRC

DEGRON score: 0.9844

ASA_SCORE: 71.4429

COIL: 0.7641

CONS_SCORE: 0.2733

DSS_SCORE: 0.5881

HELIX: 0.069

FCONS_SCORE: 0.9045

RIG_SCORE: 0.6266

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A460S	TCGA-44-6145	LUAD	TCGA	DSGVEST	DEG_SCF_TRCP1_1	0.1667
p.S453Y	TCGA-94-8491	LUSC	TCGA	DSGVEST	DEG_SCF_TRCP1_1	0.6009
p.T463M	TCGA-A5-A0G1	UCEC	TCGA	DSGVEST	DEG_SCF_TRCP1_1	0.0833
p.T463M	TCGA-GM-A5PV	BRCA	TCGA	DSGVEST	DEG_SCF_TRCP1_1	0.0833
p.Q458K	TCGA-HU-A4GT	STAD	TCGA	DSGVEST	DEG_SCF_TRCP1_1	0.2222
p.S444I	DO229015	LICA	ICGC	DSGVEST	DEG_SCF_TRCP1_1	0.2222
p.P439L	DO26772	LUSC	ICGC	DSGVEST	DEG_SCF_TRCP1_1	0.0833
p.G446D	DO222372	STAD	ICGC	DSGVEST	DEG_SCF_TRCP1_1	0.2778
p.Q440H	DO41871	UCEC	ICGC	DSGVEST	DEG_SCF_TRCP1_1	0.1111
p.P462R	DO42616	UCEC	ICGC	DSGVEST	DEG_SCF_TRCP1_1	0.1111
p.Q458E	SIDM00994	T-Lymphoblastic Leukemia	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.2222
p.Q458E	SIDM00856	Other Solid Cancers	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.2222
p.P441A	SIDM00617	Hepatocellular Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00781	Colorectal Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00057	Neuroblastoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00552	Rhabdomyosarcoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00040	Gastric Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00351	Oral Cavity Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM01682	Gastric Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SIDM00780	Colorectal Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	HARA	lung	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	TMK-1	stomach	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SNU-C2B	large_intestine	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	TE-4	oesophagus	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	JHH-2	liver	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	SAS	upper_aerodigestive_tract	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.P441A	KYM-1	soft_tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1389
p.E447K	SIDM01093	Cervical Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.3056
p.E447K	SiHa	cervix	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.3056
p.A454T	SIDM00980	Gastric Carcinoma	GDSC	DSGVEST	DEG_SCF_TRCP1_1	0.7139
p.A454T	23132-87	stomach	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.7139
p.D456G	ASH-3	thyroid	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.2778
p.D462G	ASH-3	thyroid	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.1111
p.V451M	SK-UT-1	soft_tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.6097
p.V457M	SK-UT-1	soft_tissue	COSMIC	DSGVEST	DEG_SCF_TRCP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVEST

Degron related mutations and impact score

Drug responses associated with LPIN1 mutations

All proteins holding degron of DSGVEST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14693	Phosphatidate phosphatase LPIN1	DEG_SCF_TRCP1_1	448:454	DSGVEST	BTRC	0.9844	More...