DegronMD

Uniprot ID: Q8IYB3

Source protein: Serine/arginine repetitive matrix protein 1

Source gene: SRRM1

Class: DEG_SCF_FBW7_1

Location: 415:420

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 117.9

COIL: 0.9565

CONS_SCORE: 0.365

DSS_SCORE: 0.9431

HELIX: 0.0365

FCONS_SCORE: 1.0803

RIG_SCORE: 0.5266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T416I	TCGA-33-A4WN	LUSC	TCGA	PTPQQS	DEG_SCF_FBW7_1	0.8189
p.T416I	DO219121	LUSC	ICGC	PTPQQS	DEG_SCF_FBW7_1	0.8189
p.K410R	TCGA-AG-A008	READ	TCGA	PTPQQS	DEG_SCF_FBW7_1	0.3056
p.R412W	TCGA-EO-A22R	UCEC	TCGA	PTPQQS	DEG_SCF_FBW7_1	0.25
p.P427S	DO229453	SKCA	ICGC	PTPQQS	DEG_SCF_FBW7_1	0.1389
p.P407S	DO229491	SKCA	ICGC	PTPQQS	DEG_SCF_FBW7_1	0.1111
p.R407W	DO42713	UCEC	ICGC	PTPQQS	DEG_SCF_FBW7_1	0.1111
p.R427H	SIDM01006	Plasma Cell Myeloma	GDSC	PTPQQS	DEG_SCF_FBW7_1	0.1389
p.R427H	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPQQS	DEG_SCF_FBW7_1	0.1389
p.R427H	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPQQS	DEG_SCF_FBW7_1	0.1389
p.V428I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTPQQS	DEG_SCF_FBW7_1	0.1111
p.A405V	SIDM00847	Rhabdomyosarcoma	GDSC	PTPQQS	DEG_SCF_FBW7_1	0.0556
p.A405V	ACH-000169	Sarcoma	CCLE	PTPQQS	DEG_SCF_FBW7_1	0.0556
p.A405V	RD	soft_tissue	COSMIC	PTPQQS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SCF_FBW7_1	415:420	PTPQQS	FBXW7	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons