DegronMD

Uniprot ID: Q8IYB3

Source protein: Serine/arginine repetitive matrix protein 1

Source gene: SRRM1

Class: DEG_SPOP_SBC_1

Location: 691:695

E3 ligase: SPOP

DEGRON score: 0.9405

ASA_SCORE: 110.28

COIL: 0.9686

CONS_SCORE: 0.3417

DSS_SCORE: 0.9246

HELIX: 0.0152

FCONS_SCORE: 0.9326

RIG_SCORE: 0.4307

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V700I	TCGA-36-2547	OV	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P697L	TCGA-55-7994	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2778
p.P697L	ES-2	ovary	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.S683L	TCGA-AA-3864	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.5556
p.S683L	TCGA-W3-AA1R	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.5556
p.S705L	TCGA-B5-A3FC	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.5
p.S705L	TCGA-SJ-A6ZI	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.5
p.Q692E	TCGA-CN-4723	HNSC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.5633
p.R689Q	TCGA-D1-A17Q	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2778
p.R689Q	DO41903	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.R689Q	SIDM00243	Other Solid Cancers	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.R689Q	ACH-002288	Embryonal Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.2778
p.R689Q	NEC8	testis	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.P686S	TCGA-F4-6570	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1944
p.R701Q	TCGA-F5-6814	READ	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1667
p.R701Q	DO50732	ORCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.R701Q	DO36556	READ	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.P695S	DO10443	COAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.6752
p.S692L	DO8490	COAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7667
p.S692L	DO51275	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7667
p.Q701E	DO14830	HNSC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.R683L	DO228948	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.5556
p.S703F	DO220891	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.A682T	DO38202	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.R687W	SIDM02041	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.R687W	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.P688L	SIDM00861	Ovarian Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.25
p.P688L	ACH-000906	Ovarian Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.25
p.P688L	ES-2	ovary	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.25
p.R688Q	NEC8	testis	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.25
p.S705P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.5
p.R698Q	NEC8	testis	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.25
p.P687L	ES-2	ovary	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with SRRM1 mutations

All proteins holding degron of PQTSS