DegronMD - Q6K0P9(PYHIN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q440H	TCGA-05-5425	LUAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.2778
p.Q440H	TCGA-05-5425	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.F451L	TCGA-13-0910	OV	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.2778
p.F451L	TCGA-13-0910	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.P114S	TCGA-18-3409	LUSC	TCGA	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation altering degron motif	0.6752
p.P114S	DO26444	LUSC	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation altering degron motif	0.6752
p.P186Q	TCGA-44-8120	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.25
p.P186Q	DO45402	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.25
p.G166V	TCGA-49-AARO	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.3056
p.G166V	DO218924	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.3056
p.S191L	TCGA-55-7914	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1111
p.S191L	DO23866	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1111
p.G460V	TCGA-55-8208	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.R175H	TCGA-66-2792	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.R175H	TCGA-66-2792	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2222
p.R175H	DO26451	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.R175H	DO26451	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2222
p.R175H	DO50416	PRAD	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.R175H	DO50416	PRAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2222
p.R175H	ACH-001857	Bile Duct Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.R175H	ACH-001857	Bile Duct Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2222
p.P439S	TCGA-78-7155	LUAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.P439S	TCGA-78-7155	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439S	TCGA-EE-A181	SKCM	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.P439S	TCGA-EE-A181	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.A167D	TCGA-80-5611	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7793
p.A167D	DO23822	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7793
p.T171A	TCGA-91-6829	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7139
p.T171A	DO23564	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7139
p.T107M	TCGA-A5-A0G2	UCEC	TCGA	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1389
p.T107M	DO218709	BRCA	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1389
p.T107M	DO230341	COCA	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1389
p.T107M	DO41235	UCEC	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1389
p.E157V	TCGA-A5-A0G2	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.E157V	DO41235	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T126A	TCGA-AA-3713	COAD	TCGA	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1667
p.T126A	DO8400	COAD	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1667
p.S191A	TCGA-AZ-6598	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1111
p.S191A	DO10276	COAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1111
p.P459T	TCGA-B5-A11U	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.P459T	TCGA-B5-A11U	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.P161S	TCGA-B5-A3FC	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.P161S	TCGA-FZ-5921	PAAD	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.P161S	DO51688	PAAD	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.P161S	DO41871	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.S122R	TCGA-BR-8372	STAD	TCGA	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.2778
p.S122R	DO47873	STAD	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.2778
p.P439T	TCGA-C8-A12P	BRCA	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.P439T	TCGA-C8-A12P	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.A118V	TCGA-CG-4306	STAD	TCGA	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation altering degron motif	0.5825
p.A118V	DO38567	STAD	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation altering degron motif	0.5825
p.G129E	TCGA-D3-A3CB	SKCM	TCGA	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.0833
p.G129E	DO47386	SKCM	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.0833
p.S448G	TCGA-D7-A4YV	STAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.5882
p.S448G	TCGA-D7-A4YV	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6993
p.S162F	TCGA-EE-A29S	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1944
p.S162F	DO37936	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1944
p.T192A	TCGA-EE-A2GR	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0833
p.T192A	DO37996	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0833
p.S183L	TCGA-EE-A2M6	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7667
p.S183L	DO222514	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7667
p.S183L	DO37976	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7667
p.S183L	ACH-001414	Bladder Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7667
p.S182L	TCGA-EO-A22U	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7667
p.S182L	DO43755	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7667
p.P179S	TCGA-FW-A3R5	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.6752
p.P179S	DO37406	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.6752
p.P439L	TCGA-FW-A3R5	SKCM	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.P439L	TCGA-FW-A3R5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.H193Y	DO225054	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0556
p.A452S	DO7792	COAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.A452S	DO7792	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.D448E	DO8674	COAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6758
p.D448E	DO8674	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6758
p.K447R	DO50340	ESAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.7237
p.K447R	DO50340	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7237
p.H193R	DO234470	ESAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0556
p.A172V	DO234437	ESAD	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.3056
p.A172V	DO234437	ESAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1389
p.T436I	DO233173	GACA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1667
p.T436I	DO233173	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.R175C	DO233757	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.R175C	DO233757	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2222
p.P117T	DO233716	GACA	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation altering degron motif	0.7031
p.A167S	DO233746	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7588
p.Q109P	DO233918	GACA	ICGC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1944
p.A457T	DO20776	KIRP	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1111
p.A457T	DO20776	KIRP	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.R460I	DO228948	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.S455L	DO228850	LICA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1667
p.S455L	DO228850	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.K447N	DO229019	LICA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6918
p.K447N	DO229019	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6918
p.D450Y	DO229008	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7325
p.H193Q	DO23576	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0556
p.H193Q	DO223725	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0556
p.G451V	DO51192	LUAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.2778
p.G451V	DO51192	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.P179L	DO222662	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7582
p.P179L	SIDM00140	Melanoma	GDSC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7582
p.P179L	ACH-000968	Skin Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7582
p.P179L	COLO-792	skin	COSMIC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7582
p.F442L	DO29186	OV	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6981
p.S439G	DO47777	STAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.S439G	DO47777	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P450T	DO40804	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7031
p.A190T	DO41199	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1389
p.K108R	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation substituting flanking lysine	0.2778
p.K108R	ACH-001363	Lung Cancer	CCLE	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation substituting flanking lysine	0.2778
p.K108R	NCI-H2135	lung	COSMIC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation substituting flanking lysine	0.2778
p.S190F	SIDM00619	Thyroid Gland Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1389
p.S190F	ACH-002397	Thyroid Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1389
p.S190F	KMH-2	thyroid	COSMIC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1389
p.Q109R	SIDM00498	Colorectal Carcinoma	GDSC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1944
p.Q109R	ACH-000970	Colon/Colorectal Cancer	CCLE	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1944
p.Q109R	SNU-C5	large intestine	COSMIC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.1944
p.V112L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.2778
p.V112L	ACH-000589	Lung Cancer	CCLE	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.2778
p.V112L	NCI-H1437	lung	COSMIC	PATPACT	DEG_SCF_FBW7_1	114:120	Mutation rewiring degron network	0.2778
p.P432T	SIDM00988	Kidney Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.P432T	ACH-000792	Kidney Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.P432T	BFTC-909	kidney	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.D455N	SIDM01679	Small Cell Lung Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1667
p.D455N	SIDM01679	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.D455N	ACH-000523	Lung Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1667
p.D455N	ACH-000523	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.P178R	SIDM00159	Biliary Tract Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.P178R	SIDM00159	Biliary Tract Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.3056
p.S181F	KMH-2	thyroid	COSMIC	PQTSS	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.7982
p.P170L	COLO-792	skin	COSMIC	ASTST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7582
p.D448N	HCC1569	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6932
p.D448N	HCC1569	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6932
p.D457N	HCC1569	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1111
p.D457N	HCC1569	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PYHIN1

UniProt ID: Q6K0P9

Entrez ID: 149628

Protein name: Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PYHIN1 in