DegronMD

Uniprot ID: Q6K0P9

Source protein: Pyrin and HIN domain-containing protein 1

Source gene: PYHIN1

Class: DEG_SCF_FBW7_1

Location: 442:449

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 78.275

COIL: 0.9254

CONS_SCORE: 0.6007

DSS_SCORE: 0.7925

HELIX: 0.0534

FCONS_SCORE: 1.1926

RIG_SCORE: 0.5305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q440H	TCGA-05-5425	LUAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.2778
p.F451L	TCGA-13-0910	OV	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.2778
p.P439S	TCGA-78-7155	LUAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.P439S	TCGA-EE-A181	SKCM	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.P459T	TCGA-B5-A11U	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.P439T	TCGA-C8-A12P	BRCA	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.S448G	TCGA-D7-A4YV	STAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.5882
p.P439L	TCGA-FW-A3R5	SKCM	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.A452S	DO7792	COAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.D448E	DO8674	COAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.6758
p.K447R	DO50340	ESAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.7237
p.T436I	DO233173	GACA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.A457T	DO20776	KIRP	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.1111
p.S455L	DO228850	LICA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.K447N	DO229019	LICA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.6918
p.G451V	DO51192	LUAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.2778
p.F442L	DO29186	OV	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.6981
p.S439G	DO47777	STAD	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.P432T	SIDM00988	Kidney Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.P432T	ACH-000792	Kidney Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.P432T	BFTC-909	kidney	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.D455N	SIDM01679	Small Cell Lung Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.D455N	ACH-000523	Lung Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.D448N	HCC1569	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.6932
p.D457N	HCC1569	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16666	Gamma-interferon-inducible protein 16	DEG_SCF_FBW7_1	432:439	PPTTPSSS	FBXW7	0.997	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SCF_FBW7_1	442:449	PPTTPSSS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons