DegronMD - Q16666(IFI16)

FUNCTION: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E183D	TCGA-06-1084	GBM	TCGA	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.E183D	DO11106	GBM	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.P492Q	TCGA-19-2631	GBM	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation altering degron motif	0.7035
p.P492Q	DO13809	GBM	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation altering degron motif	0.7035
p.V559I	TCGA-29-2431	OV	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1111
p.V559I	DO28040	OV	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1111
p.E536Q	TCGA-86-8056	LUAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking phosphorylation signal	0.5556
p.E536Q	DO24950	LUAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking phosphorylation signal	0.5556
p.P433T	TCGA-A2-A0CT	BRCA	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.5919
p.P433T	DO4780	BRCA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.5919
p.P422L	TCGA-A5-A0G1	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0556
p.P422L	DO42472	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0556
p.K541N	TCGA-A5-A0G2	UCEC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.25
p.K541N	TCGA-BS-A0UV	UCEC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.25
p.K541N	DO41235	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.25
p.K541N	DO42793	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.25
p.K170N	TCGA-AA-3666	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.25
p.K170N	TCGA-AZ-6598	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.25
p.K170N	DO9042	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.25
p.K170N	DO10276	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.25
p.V554A	TCGA-AA-3950	COAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.25
p.V554A	DO9202	COAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.25
p.D447Y	TCGA-AA-A010	COAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1111
p.S495N	TCGA-AD-A5EJ	COAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation altering degron motif	0.7069
p.S495N	DO50090	COAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation altering degron motif	0.7069
p.S179G	TCGA-AP-A051	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6993
p.S179G	DO42673	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6993
p.I449L	TCGA-AP-A051	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0556
p.I449L	DO42673	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0556
p.P176S	TCGA-AP-A0LM	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.3056
p.P176S	DO43306	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.3056
p.A189V	TCGA-AP-A1DV	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1111
p.A189V	DO43186	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1111
p.A122T	TCGA-AX-A1CE	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.A122T	DO42280	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.V534I	TCGA-AX-A2HD	UCEC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.V534I	DO42608	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.Q430E	TCGA-BB-4223	HNSC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.2778
p.Q430E	DO15607	HNSC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.2778
p.S424N	TCGA-BG-A222	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1111
p.S424N	DO42977	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1111
p.S424N	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1111
p.K116Q	TCGA-CA-6717	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking ubiquitination signal	0.6667
p.K116Q	DO8264	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking ubiquitination signal	0.6667
p.Q486L	TCGA-CC-5264	LIHC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2778
p.Q486L	DO23053	LIHC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2778
p.L497V	TCGA-CD-A487	STAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2778
p.L497V	DO47719	STAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2778
p.R556Q	TCGA-CM-5349	COAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1944
p.R556Q	DO8487	COAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1944
p.M487I	TCGA-DU-6392	LGG	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.3056
p.M487I	DO22237	LGG	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.3056
p.V557L	TCGA-E2-A105	BRCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking ubiquitination signal	0.6111
p.V557L	DO3536	BRCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking ubiquitination signal	0.6111
p.K558M	TCGA-E2-A10C	BRCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1389
p.K558M	DO1334	BRCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1389
p.P109H	TCGA-EE-A20F	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.6583
p.P109H	DO37961	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.6583
p.E479K	TCGA-FD-A3B5	BLCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.0833
p.E479K	DO714	BLCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.0833
p.E121Q	TCGA-GV-A3JZ	BLCA	TCGA	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.E121Q	DO773	BLCA	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.E423K	TCGA-IR-A3LH	CESC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0833
p.E423K	DO44381	CESC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0833
p.S106L	TCGA-P3-A6T4	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking phosphorylation signal	0.7222
p.S106L	DO49042	HNSC	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking phosphorylation signal	0.7222
p.P429S	TCGA-PG-A7D5	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.25
p.P429S	DO52420	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.25
p.E551Q	TCGA-VS-A953	CESC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation altering degron motif	0.6744
p.E551Q	DO219727	CESC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation altering degron motif	0.6744
p.T117P	TCGA-X8-AAAR	ESCA	TCGA	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking phosphorylation signal	0.6389
p.T117P	DO234236	ESAD	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking phosphorylation signal	0.6389
p.T117P	DO233897	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking phosphorylation signal	0.6389
p.Q486H	TCGA-XF-AAMG	BLCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2778
p.Q486H	DO219049	BLCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2778
p.P502Q	DO52620	BOCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.1389
p.S180Y	DO225357	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.S180Y	DO222762	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.S180Y	DO51053	PRAD	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.S180Y	SIDM00118	Colorectal Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.S180Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.S180Y	HCC2998	large intestine	COSMIC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.D503G	DO1589	BRCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.1111
p.S179T	DO229010	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO229013	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO229003	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO229005	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO229480	LAML	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO229505	LAML	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO228947	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO230993	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.S179T	DO231007	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6005
p.P485L	DO234284	ESAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.S110A	DO234443	ESAD	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.87
p.L553V	DO233689	GACA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.2778
p.L553V	DO25622	LUAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.2778
p.L553V	DO47837	STAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.2778
p.S113I	DO229019	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.3056
p.S549I	DO229019	LICA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation altering degron motif	0.7341
p.V534L	DO229032	LICA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.V534L	SIDM00683	Prostate Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.V534L	ACH-000977	lymph node	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.V534L	LNCaP-Clone-FGC	prostate	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.M431I	DO229038	LICA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.A549S	DO220881	MELA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation altering degron motif	0.7588
p.P545L	DO220900	MELA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation altering degron motif	0.6471
p.P545L	DO47480	SKCM	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation altering degron motif	0.6471
p.P502A	DO222447	MELA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.1389
p.F500L	DO41488	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation blocking ubiquitination signal	0.6389
p.F500L	DO41416	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation blocking ubiquitination signal	0.6389
p.T499M	DO42673	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.2222
p.S495R	SIDM01300	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation altering degron motif	0.7427
p.T498I	SIDM01156	Small Cell Lung Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM00629	Breast Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM01483	Melanoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM00472	Ovarian Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM00244	Neuroblastoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM00841	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM00836	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM00839	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.T498I	SIDM01546	Kidney Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.25
p.F440L	SIDM01261	Breast Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.F440L	SIDM00314	Breast Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.F440L	ACH-000097	Breast Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.F440L	ACH-002208	Breast Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.F440L	YMB-1-E	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.K99R	SIDM01071	Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking ubiquitination signal	0.5278
p.K99R	HCC-33	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking ubiquitination signal	0.5278
p.K558N	SIDM00040	Gastric Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1389
p.K558N	TMK-1	stomach	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.1389
p.S480N	SIDM01148	Plasma Cell Myeloma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation blocking phosphorylation signal	0.5556
p.S480N	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation blocking phosphorylation signal	0.5556
p.L426R	SIDM00841	Colorectal Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1667
p.L426R	ACH-000651	Colon/Colorectal Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1667
p.L426R	ACH-000842	Colon/Colorectal Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1667
p.L426R	SW620	large intestine	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1667
p.E121G	SIDM00537	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.E121G	ACH-001345	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.E121G	GP5d	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.P167L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.P167L	ACH-000875	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.P167L	NCI-H2347	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.P433R	SIDM00528	Breast Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.6401
p.P433R	ACH-000934	Breast Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.6401
p.P433R	MDA-MB-361	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.6401
p.Q540R	SIDM01609	Endometrial Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking phosphorylation signal	0.6667
p.Q540R	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking phosphorylation signal	0.6667
p.S501R	ACH-000815	Lymphoma	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.1667
p.S501R	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.1667
p.S536R	ACH-000929	Lung Cancer	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking phosphorylation signal	0.5556
p.S536R	NCI-H2110	lung	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation blocking phosphorylation signal	0.5556
p.S480R	NCI-H2110	lung	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation blocking phosphorylation signal	0.5556
p.S445R	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1667
p.V478L	LNCaP-Clone-FGC	prostate	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.0556
p.P104H	MN-60	haematopoietic and lymphoid tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.2222
p.P534H	MN-60	haematopoietic and lymphoid tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.P104A	SKN	soft tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.2222
p.K502N	TMK-1	stomach	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	488:495	Mutation rewiring degron network	0.1389
p.P534A	SKN	soft tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	544:551	Mutation rewiring degron network	0.0556
p.E186K	EW-13	bone	COSMIC	PNSSS	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFI16

UniProt ID: Q16666

Entrez ID: 3428

Protein name: Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFI16 in