DegronMD

Uniprot ID: Q16666

Source protein: Gamma-interferon-inducible protein 16

Source gene: IFI16

Class: DEG_SCF_FBW7_1

Location: 488:495

E3 ligase: FBXW7

DEGRON score: 0.968

ASA_SCORE: 83.2625

COIL: 0.9386

CONS_SCORE: 0.1887

DSS_SCORE: 0.7447

HELIX: 0.0499

FCONS_SCORE: 0.7631

RIG_SCORE: 0.5577

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P492Q	TCGA-19-2631	GBM	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.7035
p.P492Q	DO13809	GBM	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.7035
p.S495N	TCGA-AD-A5EJ	COAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.7069
p.S495N	DO50090	COAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.7069
p.Q486L	TCGA-CC-5264	LIHC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.Q486L	DO23053	LIHC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.L497V	TCGA-CD-A487	STAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.L497V	DO47719	STAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.M487I	TCGA-DU-6392	LGG	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.3056
p.M487I	DO22237	LGG	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.3056
p.E479K	TCGA-FD-A3B5	BLCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.0833
p.E479K	DO714	BLCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.0833
p.Q486H	TCGA-XF-AAMG	BLCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.Q486H	DO219049	BLCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.P502Q	DO52620	BOCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.1389
p.D503G	DO1589	BRCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.1111
p.P485L	DO234284	ESAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.P502A	DO222447	MELA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.1389
p.F500L	DO41488	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.6389
p.F500L	DO41416	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.6389
p.T499M	DO42673	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2222
p.S495R	SIDM01300	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.7427
p.T498I	SIDM01156	Small Cell Lung Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM00629	Breast Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM01483	Melanoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM00472	Ovarian Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM00244	Neuroblastoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM00841	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM00836	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM00839	Colorectal Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.T498I	SIDM01546	Kidney Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.S480N	SIDM01148	Plasma Cell Myeloma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.S480N	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.S501R	ACH-000815	Lymphoma	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	0.1667
p.S501R	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.1667
p.S480R	NCI-H2110	lung	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.V478L	LNCaP-Clone-FGC	prostate	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.K502N	TMK-1	stomach	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTPSSS

Degron related mutations and impact score

Drug responses associated with IFI16 mutations

All proteins holding degron of PPSTPSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16666	Gamma-interferon-inducible protein 16	DEG_SCF_FBW7_1	488:495	PPSTPSSS	FBXW7	0.968	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SCF_FBW7_1	544:551	PPSTPSSS	FBXW7	0.9064	More...