DegronMD

Uniprot ID: Q16666

Source protein: Gamma-interferon-inducible protein 16

Source gene: IFI16

Class: DEG_SCF_FBW7_1

Location: 544:551

E3 ligase: FBXW7

DEGRON score: 0.9064

ASA_SCORE: 75.5625

COIL: 0.9024

CONS_SCORE: 0.3091

DSS_SCORE: 0.718

HELIX: 0.0789

FCONS_SCORE: 0.9007

RIG_SCORE: 0.5601

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V559I	TCGA-29-2431	OV	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.1111
p.V559I	DO28040	OV	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.1111
p.E536Q	TCGA-86-8056	LUAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.E536Q	DO24950	LUAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.K541N	TCGA-A5-A0G2	UCEC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.K541N	TCGA-BS-A0UV	UCEC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.K541N	DO41235	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.K541N	DO42793	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.V554A	TCGA-AA-3950	COAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.V554A	DO9202	COAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.25
p.V534I	TCGA-AX-A2HD	UCEC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.V534I	DO42608	UCEC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.R556Q	TCGA-CM-5349	COAD	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.1944
p.R556Q	DO8487	COAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.1944
p.V557L	TCGA-E2-A105	BRCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.6111
p.V557L	DO3536	BRCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.6111
p.K558M	TCGA-E2-A10C	BRCA	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.1389
p.K558M	DO1334	BRCA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.1389
p.E551Q	TCGA-VS-A953	CESC	TCGA	PPSTPSSS	DEG_SCF_FBW7_1	0.6744
p.E551Q	DO219727	CESC	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.6744
p.L553V	DO233689	GACA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.L553V	DO25622	LUAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.L553V	DO47837	STAD	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.2778
p.S549I	DO229019	LICA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.7341
p.V534L	DO229032	LICA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.V534L	SIDM00683	Prostate Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.V534L	ACH-000977	lymph_node	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.V534L	LNCaP-Clone-FGC	prostate	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.A549S	DO220881	MELA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.7588
p.P545L	DO220900	MELA	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.6471
p.P545L	DO47480	SKCM	ICGC	PPSTPSSS	DEG_SCF_FBW7_1	0.6471
p.K558N	SIDM00040	Gastric Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.1389
p.K558N	TMK-1	stomach	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.1389
p.Q540R	SIDM01609	Endometrial Carcinoma	GDSC	PPSTPSSS	DEG_SCF_FBW7_1	0.6667
p.Q540R	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	0.6667
p.S536R	ACH-000929	Lung Cancer	CCLE	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.S536R	NCI-H2110	lung	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.5556
p.P534H	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556
p.P534A	SKN	soft_tissue	COSMIC	PPSTPSSS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTPSSS

Degron related mutations and impact score

Drug responses associated with IFI16 mutations

All proteins holding degron of PPSTPSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16666	Gamma-interferon-inducible protein 16	DEG_SCF_FBW7_1	488:495	PPSTPSSS	FBXW7	0.968	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SCF_FBW7_1	544:551	PPSTPSSS	FBXW7	0.9064	More...