DegronMD

Uniprot ID: Q16666

Source protein: Gamma-interferon-inducible protein 16

Source gene: IFI16

Class: DEG_SCF_FBW7_1

Location: 432:439

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 83.5375

COIL: 0.9383

CONS_SCORE: 0.3353

DSS_SCORE: 0.6965

HELIX: 0.0431

FCONS_SCORE: 1.1861

RIG_SCORE: 0.6043

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P433T	TCGA-A2-A0CT	BRCA	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.5919
p.P433T	DO4780	BRCA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.5919
p.P422L	TCGA-A5-A0G1	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.P422L	DO42472	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.D447Y	TCGA-AA-A010	COAD	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.1111
p.I449L	TCGA-AP-A051	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.I449L	DO42673	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.0556
p.Q430E	TCGA-BB-4223	HNSC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.2778
p.Q430E	DO15607	HNSC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.2778
p.S424N	TCGA-BG-A222	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.1111
p.S424N	DO42977	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.1111
p.S424N	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.1111
p.E423K	TCGA-IR-A3LH	CESC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.0833
p.E423K	DO44381	CESC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.0833
p.P429S	TCGA-PG-A7D5	UCEC	TCGA	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.P429S	DO52420	UCEC	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.25
p.M431I	DO229038	LICA	ICGC	PPTTPSSS	DEG_SCF_FBW7_1	0.3056
p.F440L	SIDM01261	Breast Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	0.3056
p.F440L	SIDM00314	Breast Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	0.3056
p.F440L	ACH-000097	Breast Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.3056
p.F440L	ACH-002208	Breast Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.3056
p.F440L	YMB-1-E	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.3056
p.L426R	SIDM00841	Colorectal Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.L426R	ACH-000651	Colon/Colorectal Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.L426R	ACH-000842	Colon/Colorectal Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.L426R	SW620	large_intestine	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.1667
p.P433R	SIDM00528	Breast Carcinoma	GDSC	PPTTPSSS	DEG_SCF_FBW7_1	0.6401
p.P433R	ACH-000934	Breast Cancer	CCLE	PPTTPSSS	DEG_SCF_FBW7_1	0.6401
p.P433R	MDA-MB-361	breast	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.6401
p.S445R	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTPSSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16666	Gamma-interferon-inducible protein 16	DEG_SCF_FBW7_1	432:439	PPTTPSSS	FBXW7	0.997	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SCF_FBW7_1	442:449	PPTTPSSS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTPSSS

Degron related mutations and impact score

Drug responses associated with IFI16 mutations

All proteins holding degron of PPTTPSSS