DegronMD

Uniprot ID: Q16666

Source protein: Gamma-interferon-inducible protein 16

Source gene: IFI16

Class: DEG_SPOP_SBC_1

Location: 177:181

E3 ligase: SPOP

DEGRON score: 0.9508

ASA_SCORE: 83.14

COIL: 0.9346

CONS_SCORE: 0.4067

DSS_SCORE: 0.7125

HELIX: 0.0512

FCONS_SCORE: 0.896

RIG_SCORE: 0.494

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E183D	TCGA-06-1084	GBM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.2778
p.E183D	DO11106	GBM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.K170N	TCGA-AA-3666	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.25
p.K170N	TCGA-AZ-6598	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.25
p.K170N	DO9042	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.25
p.K170N	DO10276	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.25
p.S179G	TCGA-AP-A051	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.6993
p.S179G	DO42673	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6993
p.P176S	TCGA-AP-A0LM	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.3056
p.P176S	DO43306	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.A189V	TCGA-AP-A1DV	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1111
p.A189V	DO43186	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1111
p.S180Y	DO225357	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.712
p.S180Y	DO222762	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.712
p.S180Y	DO51053	PRAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.712
p.S180Y	SIDM00118	Colorectal Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.712
p.S180Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.712
p.S180Y	HCC2998	large_intestine	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.712
p.S179T	DO229010	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO229013	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO229003	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO229005	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO229480	LAML	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO229505	LAML	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO228947	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO230993	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.S179T	DO231007	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6005
p.P167L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.0556
p.P167L	ACH-000875	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.0556
p.P167L	NCI-H2347	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.0556
p.E186K	EW-13	bone	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with IFI16 mutations

All proteins holding degron of PNSSS