DegronMD - Q96N67(DOCK7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D175H	TCGA-17-Z031	LUAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1111
p.S201L	TCGA-18-3409	LUSC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0556
p.S201L	TCGA-EE-A2MR	SKCM	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0556
p.S201L	TCGA-F7-8489	HNSC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0556
p.S201L	DO14319	HNSC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0556
p.S201L	DO26444	LUSC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0556
p.S201L	DO37819	SKCM	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0556
p.L198F	TCGA-49-6742	LUAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1111
p.L198F	TCGA-BK-A6W3	UCEC	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1111
p.L198F	DO25622	LUAD	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1111
p.L198F	DO50076	UCEC	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1111
p.P867S	TCGA-55-8506	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.P867S	DO45390	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.G868A	TCGA-63-6202	LUSC	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2222
p.G868A	DO26560	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2222
p.L870F	TCGA-77-6845	LUSC	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.L870F	TCGA-CN-6995	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.L870F	DO14854	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.L870F	DO26635	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.I545M	TCGA-A2-A0EU	BRCA	TCGA	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0833
p.I545M	DO3470	BRCA	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0833
p.E218D	TCGA-A5-A0G2	UCEC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6758
p.E218D	DO41235	UCEC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6758
p.R213Q	TCGA-AG-3892	READ	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	TCGA-AJ-A3EL	UCEC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	TCGA-DU-6392	LGG	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	TCGA-EO-A22R	UCEC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	DO22237	LGG	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	DO36394	READ	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	DO41542	UCEC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.R213Q	DO42713	UCEC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6218
p.H850N	TCGA-AX-A0J0	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.H850N	DO41133	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.N857H	TCGA-B5-A1MR	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.N857H	DO41758	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.S190N	TCGA-CD-A4MG	STAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.818
p.S190N	DO48009	STAD	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.818
p.H521Y	TCGA-D1-A16F	UCEC	TCGA	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0556
p.H521Y	DO42408	UCEC	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0556
p.R854H	TCGA-D5-6927	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.R854H	TCGA-XE-A9SE	TGCT	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.R854H	DO10332	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.R854H	DO10324	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.R179C	TCGA-DE-A3KN	THCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2222
p.R179C	DO39910	THCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2222
p.D197H	TCGA-DK-A1AC	BLCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1389
p.D197H	DO514	BLCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1389
p.P1148S	TCGA-DK-A6AW	BLCA	TCGA	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.2778
p.P1148S	DO48566	BLCA	ICGC	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.2778
p.R221H	TCGA-DU-6392	LGG	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.25
p.R221H	DO22237	LGG	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.25
p.R221H	SIDM00845	Burkitt's Lymphoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.25
p.R221H	SIDM01519	Head and Neck Carcinoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.25
p.R221H	Daudi	haematopoietic and lymphoid tissue	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.25
p.R1150H	TCGA-E6-A2P9	UCEC	TCGA	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.2222
p.R1150H	DO43714	UCEC	ICGC	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.2222
p.G866C	TCGA-EE-A29P	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2778
p.G866C	DO37916	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2778
p.D197Y	TCGA-GC-A6I1	BLCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1389
p.D197Y	DO49770	BLCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1389
p.D184N	TCGA-IB-7651	PAAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.5821
p.D184N	DO46657	PAAD	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.5821
p.D197N	TCGA-KQ-A41R	BLCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1389
p.D197N	DO223592	BLCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1389
p.L202F	TCGA-NH-A6GB	COAD	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0833
p.L202F	DO50092	COAD	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0833
p.S1131Y	TCGA-Q1-A73O	CESC	TCGA	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.0833
p.S1131Y	DO51612	CESC	ICGC	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.0833
p.M181V	DO230334	COCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	DO229010	COCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	DO229003	COCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	DO51018	LAML	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00425	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00588	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00373	Endometrial Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00305	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00773	Non-Cancerous	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00611	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00075	Non-Cancerous	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00411	Pancreatic Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00491	Thyroid Gland Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00600	Thyroid Gland Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00602	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01199	Hepatocellular Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00855	Other Sarcomas	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00367	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00291	Melanoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00553	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00370	T-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01005	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00569	Osteosarcoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00296	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00581	Glioblastoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00210	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00350	Head and Neck Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00529	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00650	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01093	Cervical Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00596	Endometrial Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00489	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00252	Biliary Tract Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00564	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00488	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00276	Biliary Tract Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00844	Burkitt's Lymphoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00502	B-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00567	Other Solid Cancers	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00247	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00018	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00561	Other Blood Cancers	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00988	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00241	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01681	Non-Cancerous	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00986	Head and Neck Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00579	Neuroblastoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00543	Melanoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00996	Thyroid Gland Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00591	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00604	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00774	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00279	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00243	Other Solid Cancers	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01033	Bladder Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00359	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00628	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00192	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01463	Endometrial Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01449	Pancreatic Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01335	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00168	Head and Neck Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01577	Plasma Cell Myeloma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01526	Mesothelioma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01664	Prostate Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01781	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01432	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01494	Glioblastoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01691	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00171	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01756	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01442	Glioma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01525	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM00497	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.M181V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.2778
p.I195V	DO233950	GACA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1944
p.L528M	DO228948	LICA	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.H1153N	DO228971	LICA	ICGC	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.1389
p.L524I	DO229018	LICA	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1389
p.E544K	DO229050	LICA	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.H521R	DO23511	LIRI	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0556
p.D185N	DO27909	ORCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.5821
p.P541R	DO231498	THCA	ICGC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R227W	SIDM00915	Small Cell Lung Carcinoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0833
p.R227W	ACH-002173	Lung Cancer	CCLE	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0833
p.R227W	NCI-H378	lung	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation rewiring degron network	0.0833
p.I183V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.5965
p.I183V	ACH-002256	Leukemia	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.5965
p.I183V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.5965
p.D184Y	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.6214
p.D184Y	ACH-000893	Lung Cancer	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.6214
p.D184Y	NCI-H1651	lung	COSMIC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation altering degron motif	0.6214
p.D212V	SIDM00650	Small Cell Lung Carcinoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6674
p.D212V	ACH-002286	Lung Cancer	CCLE	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6674
p.D212V	NCI-H128	lung	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6674
p.L524P	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1389
p.L524P	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1389
p.C523Y	SIDM00596	Endometrial Carcinoma	GDSC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.C523Y	ACH-000941	Endometrial/Uterine Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.C523Y	ACH-000954	Endometrial/Uterine Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.C523Y	ACH-001517	Endometrial/Uterine Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.C523Y	HEC-1	endometrium	COSMIC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.R213P	SIDM00265	Ewing's Sarcoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6401
p.R213P	ACH-002104	Bone Cancer	CCLE	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6401
p.R213P	ES3	bone	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	211:218	Mutation altering degron motif	0.6401
p.V539I	SIDM00511	Small Cell Lung Carcinoma	GDSC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.V539I	ACH-000257	Lung Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.V539I	COR-L279	lung	COSMIC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.G869S	SIDM01049	Non-Cancerous	GDSC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1944
p.G869S	EHEB	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1944
p.N200K	SIDM00435	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.0556
p.N200K	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.0556
p.S1146F	SIDM01228	Melanoma	GDSC	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation altering degron motif	0.7982
p.S1146F	CHL-1	skin	COSMIC	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation altering degron motif	0.7982
p.W191L	SIDM01503	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.3056
p.W191L	ACH-000844	Lung Cancer	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.3056
p.Y534C	SIDM01394	Kidney Carcinoma	GDSC	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation altering degron motif	0.7087
p.Y534C	ACH-000907	Kidney Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	531:536	Mutation altering degron motif	0.7087
p.I195M	ACH-000975	Lung Cancer	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	183:190	Mutation rewiring degron network	0.1944
p.Q1137R	ACH-000984	Endometrial/Uterine Cancer	CCLE	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.25
p.V1147M	ACH-000994	Endometrial/Uterine Cancer	CCLE	LLTPPAS	DEG_SCF_FBW7_1	1140:1146	Mutation rewiring degron network	0.3056
p.H850Y	ACH-001982	Metastasis	CCLE	PNSSS	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK7

UniProt ID: Q96N67

Entrez ID: 85440

Protein name: Dedicator of cytokinesis protein 7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK7 in