DegronMD

Uniprot ID: Q96N67

Source protein: Dedicator of cytokinesis protein 7

Source gene: DOCK7

Class: DEG_SCF_FBW7_1

Location: 1140:1146

E3 ligase: FBXW7

DEGRON score: 0.9459

ASA_SCORE: 79.8286

COIL: 0.9474

CONS_SCORE: 0.2636

DSS_SCORE: 0.3119

HELIX: 0.0253

FCONS_SCORE: 0.7256

RIG_SCORE: 0.6756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1148S	TCGA-DK-A6AW	BLCA	TCGA	LLTPPAS	DEG_SCF_FBW7_1	0.2778
p.P1148S	DO48566	BLCA	ICGC	LLTPPAS	DEG_SCF_FBW7_1	0.2778
p.R1150H	TCGA-E6-A2P9	UCEC	TCGA	LLTPPAS	DEG_SCF_FBW7_1	0.2222
p.R1150H	DO43714	UCEC	ICGC	LLTPPAS	DEG_SCF_FBW7_1	0.2222
p.S1131Y	TCGA-Q1-A73O	CESC	TCGA	LLTPPAS	DEG_SCF_FBW7_1	0.0833
p.S1131Y	DO51612	CESC	ICGC	LLTPPAS	DEG_SCF_FBW7_1	0.0833
p.H1153N	DO228971	LICA	ICGC	LLTPPAS	DEG_SCF_FBW7_1	0.1389
p.S1146F	SIDM01228	Melanoma	GDSC	LLTPPAS	DEG_SCF_FBW7_1	0.7982
p.S1146F	CHL-1	skin	COSMIC	LLTPPAS	DEG_SCF_FBW7_1	0.7982
p.Q1137R	ACH-000984	Endometrial/Uterine Cancer	CCLE	LLTPPAS	DEG_SCF_FBW7_1	0.25
p.V1147M	ACH-000994	Endometrial/Uterine Cancer	CCLE	LLTPPAS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N67	Dedicator of cytokinesis protein 7	DEG_SCF_FBW7_1	1140:1146	LLTPPAS	FBXW7	0.9459	More...
Q9Y5W3	Krueppel-like factor 2	DEG_SCF_FBW7_1	242:248	LLTPPAS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons