DegronMD - Q9Y5W3(KLF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A231V	TCGA-FA-A7Q1	DLBC	TCGA	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.1389
p.A231V	DO219890	DLBC	ICGC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.1389
p.A226T	DO222427	BTCA	ICGC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.2778
p.R76H	DO223732	CESC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1944
p.A88V	DO230326	COCA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.H210Y	DO234462	ESAD	ICGC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.0833
p.H210Y	ACH-000988	Endometrial/Uterine Cancer	CCLE	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.0833
p.A229S	DO50889	LICA	ICGC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.1944
p.E77D	DO228855	MALY	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.E94A	DO228855	MALY	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.P216A	DO228855	MALY	ICGC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.25
p.T78I	DO220003	SARC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.25
p.G90D	DO229208	THCA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.G90R	DO229232	THCA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.A227T	SIDM01314	Colorectal Carcinoma	GDSC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.25
p.S93Y	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.S93Y	ACH-000983	Leukemia	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.A229T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	FGLFDD	LIG_APCC_ABBA_1	219:224	Mutation rewiring degron network	0.1944
p.A235V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LLTPPAS	DEG_SCF_FBW7_1	242:248	Mutation rewiring degron network	0.1389
p.A80T	SIDM00596	Endometrial Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.3056
p.A80T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.3056
p.V92M	SIDM01082	Oral Cavity Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1111
p.V92M	ACH-000188	Head and Neck Cancer	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1111
p.T244M	ACH-000656	Lymphoma	CCLE	LLTPPAS	DEG_SCF_FBW7_1	242:248	Mutation altering degron motif	0.8534

Kaplan plot for KLF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF2

UniProt ID: Q9Y5W3

Entrez ID: 10365

Protein name: Krueppel-like factor 2 (Lung krueppel-like factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF2 in