DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LLTPPAS
Uniprot ID:
Q9Y5W3
Source protein:
Krueppel-like factor 2
Source gene:
KLF2
Class:
DEG_SCF_FBW7_1
Location:
242:248
E3 ligase:
FBXW7
DEGRON score:
0.9994
ASA_SCORE:
81.2
COIL:
0.9499
CONS_SCORE:
0.5227
DSS_SCORE:
0.4314
HELIX:
0.0193
FCONS_SCORE:
1.0857
RIG_SCORE:
0.6866
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A235V
SIDM01263
T-Lymphoblastic Leukemia
GDSC
LLTPPAS
DEG_SCF_FBW7_1
0.1389
p.T244M
ACH-000656
Lymphoma
CCLE
LLTPPAS
DEG_SCF_FBW7_1
0.8534
Drug responses associated with KLF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLTPPAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96N67
Dedicator of cytokinesis protein 7
DEG_SCF_FBW7_1
1140:1146
LLTPPAS
FBXW7
0.9459
More...
Q9Y5W3
Krueppel-like factor 2
DEG_SCF_FBW7_1
242:248
LLTPPAS
FBXW7
0.9994
More...