DegronMD

Uniprot ID: Q9Y5W3

Source protein: Krueppel-like factor 2

Source gene: KLF2

Class: LIG_APCC_ABBA_1

Location: 219:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8883

ASA_SCORE: 74.2

COIL: 0.6717

CONS_SCORE: 0.4196

DSS_SCORE: 0.25

HELIX: 0.2945

FCONS_SCORE: 1.2493

RIG_SCORE: 0.7965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A231V	TCGA-FA-A7Q1	DLBC	TCGA	FGLFDD	LIG_APCC_ABBA_1	0.1389
p.A231V	DO219890	DLBC	ICGC	FGLFDD	LIG_APCC_ABBA_1	0.1389
p.A226T	DO222427	BTCA	ICGC	FGLFDD	LIG_APCC_ABBA_1	0.2778
p.H210Y	DO234462	ESAD	ICGC	FGLFDD	LIG_APCC_ABBA_1	0.0833
p.H210Y	ACH-000988	Endometrial/Uterine Cancer	CCLE	FGLFDD	LIG_APCC_ABBA_1	0.0833
p.A229S	DO50889	LICA	ICGC	FGLFDD	LIG_APCC_ABBA_1	0.1944
p.P216A	DO228855	MALY	ICGC	FGLFDD	LIG_APCC_ABBA_1	0.25
p.A227T	SIDM01314	Colorectal Carcinoma	GDSC	FGLFDD	LIG_APCC_ABBA_1	0.25
p.A229T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	FGLFDD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5W3	Krueppel-like factor 2	LIG_APCC_ABBA_1	219:224	FGLFDD	APC,CDC20,FZR1	0.8883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons