DegronMD

Uniprot ID: Q96N67

Source protein: Dedicator of cytokinesis protein 7

Source gene: DOCK7

Class: DEG_SCF_FBW7_2

Location: 211:218

E3 ligase: FBXW7

DEGRON score: 0.7568

ASA_SCORE: 79.1375

COIL: 0.5416

CONS_SCORE: 0.2735

DSS_SCORE: 0.573

HELIX: 0.4535

FCONS_SCORE: 0.9565

RIG_SCORE: 0.7171

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S201L	TCGA-18-3409	LUSC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.0556
p.S201L	TCGA-EE-A2MR	SKCM	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.0556
p.S201L	TCGA-F7-8489	HNSC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.0556
p.S201L	DO14319	HNSC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.0556
p.S201L	DO26444	LUSC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.0556
p.S201L	DO37819	SKCM	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.0556
p.E218D	TCGA-A5-A0G2	UCEC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.6758
p.E218D	DO41235	UCEC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.6758
p.R213Q	TCGA-AG-3892	READ	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	TCGA-AJ-A3EL	UCEC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	TCGA-DU-6392	LGG	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	TCGA-EO-A22R	UCEC	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	DO22237	LGG	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	DO36394	READ	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	DO41542	UCEC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R213Q	DO42713	UCEC	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.6218
p.R221H	TCGA-DU-6392	LGG	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.25
p.R221H	DO22237	LGG	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.25
p.R221H	SIDM00845	Burkitt's Lymphoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	0.25
p.R221H	SIDM01519	Head and Neck Carcinoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	0.25
p.R221H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	0.25
p.L202F	TCGA-NH-A6GB	COAD	TCGA	LDRTPNEE	DEG_SCF_FBW7_2	0.0833
p.L202F	DO50092	COAD	ICGC	LDRTPNEE	DEG_SCF_FBW7_2	0.0833
p.R227W	SIDM00915	Small Cell Lung Carcinoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	0.0833
p.R227W	ACH-002173	Lung Cancer	CCLE	LDRTPNEE	DEG_SCF_FBW7_2	0.0833
p.R227W	NCI-H378	lung	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	0.0833
p.D212V	SIDM00650	Small Cell Lung Carcinoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	0.6674
p.D212V	ACH-002286	Lung Cancer	CCLE	LDRTPNEE	DEG_SCF_FBW7_2	0.6674
p.D212V	NCI-H128	lung	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	0.6674
p.R213P	SIDM00265	Ewing's Sarcoma	GDSC	LDRTPNEE	DEG_SCF_FBW7_2	0.6401
p.R213P	ACH-002104	Bone Cancer	CCLE	LDRTPNEE	DEG_SCF_FBW7_2	0.6401
p.R213P	ES3	bone	COSMIC	LDRTPNEE	DEG_SCF_FBW7_2	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDRTPNEE

Degron related mutations and impact score

Drug responses associated with DOCK7 mutations

All proteins holding degron of LDRTPNEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N67	Dedicator of cytokinesis protein 7	DEG_SCF_FBW7_2	211:218	LDRTPNEE	FBXW7	0.7568	More...