DegronMD

Uniprot ID: Q96N67

Source protein: Dedicator of cytokinesis protein 7

Source gene: DOCK7

Class: DEG_SCF_FBW7_1

Location: 183:190

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 72.7875

COIL: 0.8394

CONS_SCORE: 0.2986

DSS_SCORE: 0.3811

HELIX: 0.0943

FCONS_SCORE: 1.0985

RIG_SCORE: 0.6892

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D175H	TCGA-17-Z031	LUAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.1111
p.L198F	TCGA-49-6742	LUAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.1111
p.L198F	TCGA-BK-A6W3	UCEC	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.1111
p.L198F	DO25622	LUAD	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.1111
p.L198F	DO50076	UCEC	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.1111
p.S190N	TCGA-CD-A4MG	STAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.818
p.S190N	DO48009	STAD	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.818
p.R179C	TCGA-DE-A3KN	THCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.2222
p.R179C	DO39910	THCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.2222
p.D197H	TCGA-DK-A1AC	BLCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.1389
p.D197H	DO514	BLCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.1389
p.D197Y	TCGA-GC-A6I1	BLCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.1389
p.D197Y	DO49770	BLCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.1389
p.D184N	TCGA-IB-7651	PAAD	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.5821
p.D184N	DO46657	PAAD	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.5821
p.D197N	TCGA-KQ-A41R	BLCA	TCGA	IDDTPRGS	DEG_SCF_FBW7_1	0.1389
p.D197N	DO223592	BLCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.1389
p.M181V	DO230334	COCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	DO229010	COCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	DO229003	COCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	DO51018	LAML	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00425	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00588	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00373	Endometrial Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00305	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00773	Non-Cancerous	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00611	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00075	Non-Cancerous	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00411	Pancreatic Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00491	Thyroid Gland Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00600	Thyroid Gland Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00602	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01199	Hepatocellular Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00855	Other Sarcomas	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00367	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00291	Melanoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00553	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00370	T-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01005	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00569	Osteosarcoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00296	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00581	Glioblastoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00210	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00350	Head and Neck Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00529	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00650	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01093	Cervical Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00596	Endometrial Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00489	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00252	Biliary Tract Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00564	Ovarian Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00488	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00276	Biliary Tract Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00844	Burkitt's Lymphoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00502	B-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00567	Other Solid Cancers	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00247	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00018	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00561	Other Blood Cancers	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00988	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00241	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01681	Non-Cancerous	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00986	Head and Neck Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00579	Neuroblastoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00543	Melanoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00996	Thyroid Gland Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00591	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00604	Oral Cavity Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00774	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00279	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00243	Other Solid Cancers	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01033	Bladder Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00359	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00628	Breast Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00192	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01463	Endometrial Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01449	Pancreatic Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01335	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00168	Head and Neck Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01577	Plasma Cell Myeloma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01526	Mesothelioma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01664	Prostate Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01781	Gastric Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01432	Kidney Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01494	Glioblastoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01691	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00171	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01756	Chronic Myelogenous Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01442	Glioma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01525	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM00497	Colorectal Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.M181V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.2778
p.I195V	DO233950	GACA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.1944
p.D185N	DO27909	ORCA	ICGC	IDDTPRGS	DEG_SCF_FBW7_1	0.5821
p.I183V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.5965
p.I183V	ACH-002256	Leukemia	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	0.5965
p.I183V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IDDTPRGS	DEG_SCF_FBW7_1	0.5965
p.D184Y	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.6214
p.D184Y	ACH-000893	Lung Cancer	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	0.6214
p.D184Y	NCI-H1651	lung	COSMIC	IDDTPRGS	DEG_SCF_FBW7_1	0.6214
p.N200K	SIDM00435	Acute Myeloid Leukemia	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.0556
p.N200K	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	IDDTPRGS	DEG_SCF_FBW7_1	0.0556
p.W191L	SIDM01503	Small Cell Lung Carcinoma	GDSC	IDDTPRGS	DEG_SCF_FBW7_1	0.3056
p.W191L	ACH-000844	Lung Cancer	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	0.3056
p.I195M	ACH-000975	Lung Cancer	CCLE	IDDTPRGS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IDDTPRGS

Degron related mutations and impact score

Drug responses associated with DOCK7 mutations

All proteins holding degron of IDDTPRGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N67	Dedicator of cytokinesis protein 7	DEG_SCF_FBW7_1	183:190	IDDTPRGS	FBXW7	0.9995	More...