DegronMD

Uniprot ID: Q96N67

Source protein: Dedicator of cytokinesis protein 7

Source gene: DOCK7

Class: LIG_APCC_ABBA_1

Location: 531:536

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8768

ASA_SCORE: 65.4833

COIL: 0.7803

CONS_SCORE: 0.3318

DSS_SCORE: 0.2666

HELIX: 0.1097

FCONS_SCORE: 1.0096

RIG_SCORE: 0.8177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I545M	TCGA-A2-A0EU	BRCA	TCGA	VKLYPD	LIG_APCC_ABBA_1	0.0833
p.I545M	DO3470	BRCA	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.0833
p.H521Y	TCGA-D1-A16F	UCEC	TCGA	VKLYPD	LIG_APCC_ABBA_1	0.0556
p.H521Y	DO42408	UCEC	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.0556
p.L528M	DO228948	LICA	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.25
p.L524I	DO229018	LICA	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.1389
p.E544K	DO229050	LICA	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.1111
p.H521R	DO23511	LIRI	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.0556
p.P541R	DO231498	THCA	ICGC	VKLYPD	LIG_APCC_ABBA_1	0.1944
p.L524P	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VKLYPD	LIG_APCC_ABBA_1	0.1389
p.L524P	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VKLYPD	LIG_APCC_ABBA_1	0.1389
p.C523Y	SIDM00596	Endometrial Carcinoma	GDSC	VKLYPD	LIG_APCC_ABBA_1	0.1111
p.C523Y	ACH-000941	Endometrial/Uterine Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	0.1111
p.C523Y	ACH-000954	Endometrial/Uterine Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	0.1111
p.C523Y	ACH-001517	Endometrial/Uterine Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	0.1111
p.C523Y	HEC-1	endometrium	COSMIC	VKLYPD	LIG_APCC_ABBA_1	0.1111
p.V539I	SIDM00511	Small Cell Lung Carcinoma	GDSC	VKLYPD	LIG_APCC_ABBA_1	0.25
p.V539I	ACH-000257	Lung Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	0.25
p.V539I	COR-L279	lung	COSMIC	VKLYPD	LIG_APCC_ABBA_1	0.25
p.Y534C	SIDM01394	Kidney Carcinoma	GDSC	VKLYPD	LIG_APCC_ABBA_1	0.7087
p.Y534C	ACH-000907	Kidney Cancer	CCLE	VKLYPD	LIG_APCC_ABBA_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N67	Dedicator of cytokinesis protein 7	LIG_APCC_ABBA_1	531:536	VKLYPD	APC,CDC20,FZR1	0.8768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons