DegronMD

Uniprot ID: Q9H1B7

Source protein: Probable E3 ubiquitin-protein ligase IRF2BPL

Source gene: IRF2BPL

Class: DEG_SPOP_SBC_1

Location: 216:220

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 69.26

COIL: 0.769

CONS_SCORE: 0.3102

DSS_SCORE: 0.7352

HELIX: 0.205

FCONS_SCORE: 1.0124

RIG_SCORE: 0.5621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R229H	TCGA-AA-A01R	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.0833
p.R229H	DO7934	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S227Y	TCGA-EO-A22R	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.5833
p.S227Y	DO42713	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.5833
p.P209T	TCGA-ER-A19T	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1389
p.P209T	DO51251	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1389
p.N212S	DO225030	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.N212S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.N212S	ACH-000914	Lymphoma	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2222
p.N212S	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.A222G	DO229384	BTCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.R229S	DO229028	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.V225G	ACH-000955	Colon/Colorectal Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with IRF2BPL mutations

All proteins holding degron of PNSSS