DegronMD - Q9BXY5(CAPS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A89P	TCGA-4K-AA1G	TGCT	TCGA	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R66Q	TCGA-AX-A2HC	UCEC	TCGA	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7329
p.R66Q	TCGA-AZ-4315	COAD	TCGA	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7329
p.R66Q	TCGA-FI-A2D5	UCEC	TCGA	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7329
p.R66Q	DO8842	COAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7329
p.R66Q	DO41572	UCEC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7329
p.R66Q	DO41331	UCEC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7329
p.P107S	TCGA-B8-5550	KIRC	TCGA	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation rewiring degron network	0.3056
p.P107S	DO17420	KIRC	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation rewiring degron network	0.3056
p.Q105E	TCGA-D8-A147	BRCA	TCGA	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.5633
p.Q105E	DO4347	BRCA	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.5633
p.C104F	TCGA-UB-A7MB	LIHC	TCGA	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.5996
p.C104F	DO52318	LIHC	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.5996
p.A105T	DO3674	BRCA	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.7139
p.R75C	DO44096	COAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.R75C	DO40889	UCEC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.K102E	DO10324	COAD	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.7022
p.L75F	DO229010	COCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO229013	COCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO234205	ESAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO229346	LAML	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO225404	LAML	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO229047	LICA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO231114	LUSC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.L75F	DO229242	THCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.Q102E	DO48218	ESCA	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.6744
p.I71M	DO233865	GACA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7618
p.D76E	DO12454	GBM	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.G83V	DO15671	HNSC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.G83V	DO15671	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.T106N	DO229015	LICA	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.7055
p.D89E	DO229026	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.F84L	DO229026	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.H88N	DO229035	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.A89E	DO229008	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R75H	DO52318	LIHC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.N80Y	DO45121	LIRI	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1389
p.L81H	DO24596	LUAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.C78R	DO26941	LUSC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1944
p.D89G	DO46657	PAAD	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.T106A	DO51535	PACA	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.7139
p.A77T	DO228782	PRAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2222
p.G74R	DO38567	STAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.3056
p.R98Q	DO47789	STAD	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation rewiring degron network	0.25
p.R98Q	DO47789	STAD	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.R98Q	DO219773	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation rewiring degron network	0.25
p.R98Q	DO219773	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.D89Y	DO229257	THCA	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.P76S	DO229227	THCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.S75P	DO229227	THCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.R103I	DO41020	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.8102
p.Y97H	DO41758	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation rewiring degron network	0.2222
p.Y97H	DO41758	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.R104I	DO42472	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.8102
p.V101F	SIDM00510	Small Cell Lung Carcinoma	GDSC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.7068
p.V101F	COR-L303	lung	COSMIC	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation altering degron motif	0.7068
p.A89T	SIDM01045	Endometrial Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.D66G	ACH-000689	Sarcoma	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7198
p.D66G	RH-18	soft tissue	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7198
p.C78F	ACH-000979	Prostate Cancer	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1944
p.C78F	DU-145	prostate	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1944
p.Y116C	ACH-001163	Kidney Cancer	CCLE	VTPCQT	DEG_SCF_FBW7_1	101:106	Mutation rewiring degron network	0.0556
p.L81F	ACH-002264	Esophageal Cancer	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.L81F	KYSE-50	oesophagus	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.S82L	ACH-002396	Bone Cancer	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0833
p.S82L	ACH-002396	Bone Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82L	Sarc9371	bone	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0833
p.S82L	Sarc9371	bone	COSMIC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.R72H	HCC202	breast	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.8244
p.C82Y	KYSE-520	oesophagus	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0833
p.C82Y	KYSE-520	oesophagus	COSMIC	PNSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.R72C	AN3-CA	endometrium	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAPS2

UniProt ID: Q9BXY5

Entrez ID: 84698

Protein name: Calcyphosin-2 (Calcyphosine-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAPS2 in