DegronMD

Uniprot ID: Q9BXY5

Source protein: Calcyphosin-2

Source gene: CAPS2

Class: DEG_SCF_FBW7_1

Location: 101:106

E3 ligase: FBXW7

DEGRON score: 0.8989

ASA_SCORE: 72.7667

COIL: 0.903

CONS_SCORE: 0.3581

DSS_SCORE: 0.2988

HELIX: 0.0375

FCONS_SCORE: 1.1269

RIG_SCORE: 0.7961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P107S	TCGA-B8-5550	KIRC	TCGA	VTPCQT	DEG_SCF_FBW7_1	0.3056
p.P107S	DO17420	KIRC	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.3056
p.Q105E	TCGA-D8-A147	BRCA	TCGA	VTPCQT	DEG_SCF_FBW7_1	0.5633
p.Q105E	DO4347	BRCA	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.5633
p.C104F	TCGA-UB-A7MB	LIHC	TCGA	VTPCQT	DEG_SCF_FBW7_1	0.5996
p.C104F	DO52318	LIHC	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.5996
p.A105T	DO3674	BRCA	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.7139
p.K102E	DO10324	COAD	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.7022
p.Q102E	DO48218	ESCA	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.6744
p.T106N	DO229015	LICA	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.7055
p.T106A	DO51535	PACA	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.7139
p.R98Q	DO47789	STAD	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.25
p.R98Q	DO219773	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.25
p.R103I	DO41020	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.8102
p.Y97H	DO41758	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.2222
p.R104I	DO42472	UCEC	ICGC	VTPCQT	DEG_SCF_FBW7_1	0.8102
p.V101F	SIDM00510	Small Cell Lung Carcinoma	GDSC	VTPCQT	DEG_SCF_FBW7_1	0.7068
p.V101F	COR-L303	lung	COSMIC	VTPCQT	DEG_SCF_FBW7_1	0.7068
p.Y116C	ACH-001163	Kidney Cancer	CCLE	VTPCQT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXY5	Calcyphosin-2	DEG_SCF_FBW7_1	101:106	VTPCQT	FBXW7	0.8989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons