DegronMD

Uniprot ID: Q9BXY5

Source protein: Calcyphosin-2

Source gene: CAPS2

Class: DEG_APCC_DBOX_1

Location: 65:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9816

ASA_SCORE: 51.6667

COIL: 0.703

CONS_SCORE: 0.487

DSS_SCORE: 0.4703

HELIX: 0.202

FCONS_SCORE: 1.5204

RIG_SCORE: 0.7491

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R66Q	TCGA-AX-A2HC	UCEC	TCGA	PRLDLGSLV	DEG_APCC_DBOX_1	0.7329
p.R66Q	TCGA-AZ-4315	COAD	TCGA	PRLDLGSLV	DEG_APCC_DBOX_1	0.7329
p.R66Q	TCGA-FI-A2D5	UCEC	TCGA	PRLDLGSLV	DEG_APCC_DBOX_1	0.7329
p.R66Q	DO8842	COAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.7329
p.R66Q	DO41572	UCEC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.7329
p.R66Q	DO41331	UCEC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.7329
p.R75C	DO44096	COAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.R75C	DO40889	UCEC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO229010	COCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO229013	COCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO234205	ESAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO229346	LAML	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO225404	LAML	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO229047	LICA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO231114	LUSC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.L75F	DO229242	THCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.I71M	DO233865	GACA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.7618
p.D76E	DO12454	GBM	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.25
p.G83V	DO15671	HNSC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.0556
p.R75H	DO52318	LIHC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.N80Y	DO45121	LIRI	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.1389
p.L81H	DO24596	LUAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.1111
p.C78R	DO26941	LUSC	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.1944
p.A77T	DO228782	PRAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2222
p.G74R	DO38567	STAD	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.3056
p.P76S	DO229227	THCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.25
p.S75P	DO229227	THCA	ICGC	PRLDLGSLV	DEG_APCC_DBOX_1	0.2778
p.D66G	ACH-000689	Sarcoma	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	0.7198
p.D66G	RH-18	soft_tissue	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.7198
p.C78F	ACH-000979	Prostate Cancer	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	0.1944
p.C78F	DU-145	prostate	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.1944
p.L81F	ACH-002264	Esophageal Cancer	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	0.1111
p.L81F	KYSE-50	oesophagus	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.1111
p.S82L	ACH-002396	Bone Cancer	CCLE	PRLDLGSLV	DEG_APCC_DBOX_1	0.0833
p.S82L	Sarc9371	bone	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.0833
p.R72H	HCC202	breast	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.8244
p.C82Y	KYSE-520	oesophagus	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.0833
p.R72C	AN3-CA	endometrium	COSMIC	PRLDLGSLV	DEG_APCC_DBOX_1	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLDLGSLV

Degron related mutations and impact score

Drug responses associated with CAPS2 mutations

All proteins holding degron of PRLDLGSLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXY5	Calcyphosin-2	DEG_APCC_DBOX_1	65:73	PRLDLGSLV	APC,CDC20,FZR1	0.9816	More...