DegronMD

Uniprot ID: Q16832

Source protein: Discoidin domain-containing receptor 2

Source gene: DDR2

Class: DEG_SPOP_SBC_1

Location: 672:676

E3 ligase: SPOP

DEGRON score: 0.678

ASA_SCORE: 89.04

COIL: 0.944

CONS_SCORE: 0.2307

DSS_SCORE: 0.4643

HELIX: 0.0478

FCONS_SCORE: 0.4264

RIG_SCORE: 0.5775

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S683T	TCGA-17-Z042	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1389
p.R680H	TCGA-2W-A8YY	CESC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R680H	DO223732	CESC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.L666V	TCGA-55-8507	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.L666V	DO45412	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.L666I	TCGA-AP-A056	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.L666I	TCGA-EK-A2PG	CESC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.L666I	DO49939	CESC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.L666I	DO43971	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.R680C	TCGA-D1-A103	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R680C	DO42312	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R680C	SIDM01057	Acute Myeloid Leukemia	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R680C	ACH-000081	Leukemia	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R680C	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.S674Y	TCGA-D8-A147	BRCA	TCGA	PNSSS	DEG_SPOP_SBC_1	0.712
p.S674Y	DO4347	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.712
p.S667F	TCGA-Z2-A8RT	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1944
p.S667F	DO51301	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.T681I	DO227999	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.T681I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.T681I	SIDM01577	Plasma Cell Myeloma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.T681I	EBC-1	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.D678N	DO222778	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.D678N	DO224724	PACA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.R668C	DO234413	ESAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668C	SIDM01164	Glioma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668C	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668C	ACH-000638	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668C	ACH-000883	Brain Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668C	NCI-H441	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668C	SW1783	central_nervous_system	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.E670K	DO223065	ESCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.R668H	DO233188	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668H	SIDM00889	Cervical Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668H	ACH-001333	Cervical Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668H	C-33-A	cervix	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R680L	DO229028	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.R668L	DO229045	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.S675F	DO45121	LIRI	ICGC	PNSSS	DEG_SPOP_SBC_1	0.9093
p.S675F	DO220860	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.9093
p.V682F	DO222536	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.F665C	DO222644	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1389
p.T685S	SIDM00333	Endometrial Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.T685S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.0833
p.T685S	MFE-319	endometrium	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with DDR2 mutations

All proteins holding degron of PNSSS