DegronMD - Q16832(DDR2)

GO - Biological processes (BP): biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte proliferation [GO:0035988]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; collagen fibril organization [GO:0030199]; endochondral bone growth [GO:0003416]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of kinase activity [GO:0033673]; negative regulation of necrotic cell death [GO:0060547]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of kinase activity [GO:0033674]; positive regulation of neuron death [GO:1901216]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of tissue remodeling [GO:0034103]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S683T	TCGA-17-Z042	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1389
p.R680H	TCGA-2W-A8YY	CESC	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R680H	DO223732	CESC	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.L666V	TCGA-55-8507	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.L666V	DO45412	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.L666I	TCGA-AP-A056	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.L666I	TCGA-EK-A2PG	CESC	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.L666I	DO49939	CESC	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.L666I	DO43971	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.R680C	TCGA-D1-A103	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R680C	DO42312	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R680C	SIDM01057	Acute Myeloid Leukemia	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R680C	ACH-000081	Leukemia	CCLE	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R680C	GDM-1	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.S674Y	TCGA-D8-A147	BRCA	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation altering degron motif	0.712
p.S674Y	DO4347	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation altering degron motif	0.712
p.S667F	TCGA-Z2-A8RT	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1944
p.S667F	DO51301	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1944
p.T681I	DO227999	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1944
p.T681I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1944
p.T681I	SIDM01577	Plasma Cell Myeloma	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1944
p.T681I	EBC-1	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1944
p.D678N	DO222778	COCA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2778
p.D678N	DO224724	PACA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2778
p.R668C	DO234413	ESAD	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668C	SIDM01164	Glioma	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668C	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668C	ACH-000638	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668C	ACH-000883	Brain Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668C	NCI-H441	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668C	SW1783	central nervous system	COSMIC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.E670K	DO223065	ESCA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2778
p.R668H	DO233188	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668H	SIDM00889	Cervical Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668H	ACH-001333	Cervical Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668H	C-33-A	cervix	COSMIC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R680L	DO229028	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.R668L	DO229045	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.2222
p.S675F	DO45121	LIRI	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation altering degron motif	0.9093
p.S675F	DO220860	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation altering degron motif	0.9093
p.V682F	DO222536	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1667
p.F665C	DO222644	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.1389
p.T685S	SIDM00333	Endometrial Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.0833
p.T685S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.0833
p.T685S	MFE-319	endometrium	COSMIC	PNSSS	DEG_SPOP_SBC_1	672:676	Mutation rewiring degron network	0.0833

Kaplan plot for DDR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDR2

UniProt ID: Q16832

Entrez ID: 4921

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDR2 in