DegronMD

Uniprot ID: Q8WXX7

Source protein: Autism susceptibility gene 2 protein

Source gene: AUTS2

Class: DEG_SPOP_SBC_1

Location: 1008:1012

E3 ligase: SPOP

DEGRON score: 0.7835

ASA_SCORE: 90

COIL: 0.9342

CONS_SCORE: 0.3489

DSS_SCORE: 0.8042

HELIX: 0.0502

FCONS_SCORE: 1.0118

RIG_SCORE: 0.4304

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1012F	TCGA-06-5416	GBM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.7982
p.S1012F	DO10880	GBM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.7982
p.P1006L	TCGA-AD-6964	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.2778
p.P1006L	DO8360	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.A1002V	TCGA-BF-A5ES	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.A1002V	DO219456	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.P1016Q	TCGA-CV-7102	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.2222
p.P1016Q	DO14194	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.S1021L	TCGA-EE-A2GB	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S1021L	TCGA-UF-A71D	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S1021L	DO52109	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S1021L	DO222683	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S1021L	DO37417	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.G1017R	TCGA-FR-A726	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1944
p.G1017R	DO48665	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.P1005L	TCGA-QB-A6FS	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.25
p.P1005L	DO48654	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.25
p.S1011L	DO234400	ESAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.7667
p.P1007H	DO233259	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.E1004K	DO228824	MALY	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.P1018L	DO220877	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.N1009S	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.5958
p.N1009S	ACH-000534	Lymphoma	CCLE	PNSSS	DEG_SPOP_SBC_1	0.5958
p.N1009S	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.5958
p.V1014M	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.V1014M	ACH-000015	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2778
p.V1014M	ACH-001738	Leukemia	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2778
p.V1014M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.V1013M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.N1008S	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.7069
p.P1009S	HT-29	large_intestine	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.6752
p.L1016P	A2780	ovary	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.D1017E	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with AUTS2 mutations

All proteins holding degron of PNSSS