DegronMD - O60741(HCN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q772H	TCGA-17-Z055	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.0556
p.P748L	TCGA-17-Z062	LUAD	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1389
p.P748L	TCGA-17-Z062	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.0556
p.P748L	DO23543	LIRI	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1389
p.P748L	DO23543	LIRI	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.0556
p.T771K	TCGA-55-8203	LUAD	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771K	TCGA-55-8203	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771K	DO218928	LUAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771K	DO218928	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.S770G	TCGA-66-2791	LUSC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5278
p.S770G	TCGA-66-2791	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5556
p.S770G	DO231127	LUSC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5278
p.S770G	DO231127	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5556
p.S770G	DO26435	LUSC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5278
p.S770G	DO26435	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5556
p.T762K	TCGA-92-7340	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7306
p.T762K	DO26775	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7306
p.N765H	TCGA-A6-2674	COAD	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2222
p.N765H	TCGA-A6-2674	COAD	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.25
p.N765H	DO7819	COAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2222
p.N765H	DO7819	COAD	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.25
p.T762M	TCGA-CQ-5324	HNSC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7423
p.T762M	DO233210	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7423
p.T762M	DO14383	HNSC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7423
p.E766K	TCGA-DD-AAE3	LIHC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	TCGA-DD-AAE3	LIHC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	TCGA-EB-A3XC	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	TCGA-EB-A3XC	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	TCGA-GF-A4EO	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	TCGA-GF-A4EO	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	TCGA-KQ-A41S	BLCA	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	TCGA-KQ-A41S	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	DO223593	BLCA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	DO223593	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	DO52258	LIHC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	DO52258	LIHC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	DO37579	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	DO37579	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.E766K	DO47559	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.E766K	DO47559	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2222
p.T771M	TCGA-DF-A2KU	UCEC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	TCGA-DF-A2KU	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	TCGA-EY-A215	UCEC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	TCGA-EY-A215	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	TCGA-L5-A891	ESCA	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	TCGA-L5-A891	ESCA	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	TCGA-NK-A5CX	LUSC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	TCGA-NK-A5CX	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	DO233829	GACA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	DO233829	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	DO219211	LUSC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	DO219211	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	DO223286	UCEC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	DO223286	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.T771M	DO42665	UCEC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771M	DO42665	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.P763Q	TCGA-EB-A299	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763Q	TCGA-EB-A299	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763Q	DO37794	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763Q	DO37794	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763S	TCGA-FR-A8YC	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763S	TCGA-FR-A8YC	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763S	DO50301	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763S	DO50301	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763L	TCGA-OL-A6VQ	BRCA	TCGA	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763L	TCGA-OL-A6VQ	BRCA	TCGA	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763L	DO51214	BRCA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763L	DO51214	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763L	DO228838	MALY	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763L	DO228838	MALY	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.P763L	DO50421	PRAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2778
p.P763L	DO50421	PRAD	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.3056
p.K769N	DO1073	BRCA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation substituting flanking lysine	0.2222
p.K769N	DO1073	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation substituting flanking lysine	0.25
p.T771A	DO234340	ESAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771A	DO234340	ESAD	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278
p.V20I	DO233156	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.V20I	ACH-001518	Endometrial/Uterine Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.V767A	DO233804	GACA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1667
p.V767A	DO233804	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.1944
p.Q756H	DO45163	LIRI	ICGC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.647
p.D15Y	DO228523	PRAD	ICGC	PNSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.S760I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.623
p.S760I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7341
p.S760I	ACH-000636	Leukemia	CCLE	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.623
p.S760I	ACH-000636	Leukemia	CCLE	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7341
p.S760I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.623
p.S760I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	758:762	Mutation altering degron motif	0.7341
p.Q756K	SIDM00120	Prostate Carcinoma	GDSC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.5833
p.Q756K	ACH-000979	Prostate Cancer	CCLE	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.5833
p.Q756K	DU-145	prostate	COSMIC	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.5833
p.N12S	SIDM00537	Colorectal Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.N12S	ACH-001345	Colon/Colorectal Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.T771S	ACH-001664	Gastric Cancer	CCLE	PQTPGSS	DEG_SCF_FBW7_1	755:761	Mutation blocking phosphorylation signal	0.5
p.T771S	ACH-001664	Gastric Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	758:762	Mutation blocking phosphorylation signal	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HCN1

UniProt ID: O60741

Entrez ID: 348980

Protein name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HCN1 in