DegronMD

Uniprot ID: O60741

Source protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Source gene: HCN1

Class: DEG_SPOP_SBC_1

Location: 758:762

E3 ligase: SPOP

DEGRON score: 0.9855

ASA_SCORE: 75.56

COIL: 0.9636

CONS_SCORE: 0.2263

DSS_SCORE: 0.9263

HELIX: 0.018

FCONS_SCORE: 0.8751

RIG_SCORE: 0.4306

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q772H	TCGA-17-Z055	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	0.0556
p.P748L	TCGA-17-Z062	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	0.0556
p.P748L	DO23543	LIRI	ICGC	PGSST	DEG_SPOP_SBC_1	0.0556
p.T771K	TCGA-55-8203	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771K	DO218928	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	0.5278
p.S770G	TCGA-66-2791	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	0.5556
p.S770G	DO231127	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	0.5556
p.S770G	DO26435	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	0.5556
p.T762K	TCGA-92-7340	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	0.7306
p.T762K	DO26775	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	0.7306
p.N765H	TCGA-A6-2674	COAD	TCGA	PGSST	DEG_SPOP_SBC_1	0.25
p.N765H	DO7819	COAD	ICGC	PGSST	DEG_SPOP_SBC_1	0.25
p.T762M	TCGA-CQ-5324	HNSC	TCGA	PGSST	DEG_SPOP_SBC_1	0.7423
p.T762M	DO233210	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	0.7423
p.T762M	DO14383	HNSC	ICGC	PGSST	DEG_SPOP_SBC_1	0.7423
p.E766K	TCGA-DD-AAE3	LIHC	TCGA	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	TCGA-EB-A3XC	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	TCGA-GF-A4EO	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	TCGA-KQ-A41S	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	DO223593	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	DO52258	LIHC	ICGC	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	DO37579	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.2222
p.E766K	DO47559	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.2222
p.T771M	TCGA-DF-A2KU	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	TCGA-EY-A215	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	TCGA-L5-A891	ESCA	TCGA	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	TCGA-NK-A5CX	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	DO233829	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	DO219211	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	DO223286	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	0.5278
p.T771M	DO42665	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	0.5278
p.P763Q	TCGA-EB-A299	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763Q	DO37794	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763S	TCGA-FR-A8YC	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763S	DO50301	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763L	TCGA-OL-A6VQ	BRCA	TCGA	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763L	DO51214	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763L	DO228838	MALY	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.P763L	DO50421	PRAD	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.K769N	DO1073	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	0.25
p.T771A	DO234340	ESAD	ICGC	PGSST	DEG_SPOP_SBC_1	0.5278
p.V767A	DO233804	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	0.1944
p.S760I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PGSST	DEG_SPOP_SBC_1	0.7341
p.S760I	ACH-000636	Leukemia	CCLE	PGSST	DEG_SPOP_SBC_1	0.7341
p.S760I	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	0.7341
p.T771S	ACH-001664	Gastric Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15061	Synemin	DEG_SPOP_SBC_1	1302:1306	PGSST	SPOP	0.9781	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	758:762	PGSST	SPOP	0.9855	More...
O94875	Sorbin and SH3 domain-containing protein 2	DEG_SPOP_SBC_1	285:289	PGSST	SPOP	0.99	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	246:250	PGSST	SPOP	0.8617	More...
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	711:715	PGSST	SPOP	0.6649	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	477:481	PGSST	SPOP	0.7875	More...
P49639	Homeobox protein Hox-A1	DEG_SPOP_SBC_1	323:327	PGSST	SPOP	0.9865	More...
P52799	Ephrin-B2	DEG_SPOP_SBC_1	204:208	PGSST	SPOP	0.573	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	676:680	PGSST	SPOP	0.9143	More...
Q14541	Hepatocyte nuclear factor 4-gamma	DEG_SPOP_SBC_1	122:126	PGSST	SPOP	0.5473	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	759:763	PGSST	SPOP	0.9962	More...
Q5W0B1	ORC ubiquitin ligase 1	DEG_SPOP_SBC_1	302:306	PGSST	SPOP	0.9546	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1949:1953	PGSST	SPOP	0.9296	More...
Q86UW9	Probable E3 ubiquitin-protein ligase DTX2	DEG_SPOP_SBC_1	294:298	PGSST	SPOP	0.9802	More...
Q8IVI9	Nostrin	DEG_SPOP_SBC_1	426:430	PGSST	SPOP	0.6311	More...
Q8TER5	Rho guanine nucleotide exchange factor 40	DEG_SPOP_SBC_1	1488:1492	PGSST	SPOP	0.9989	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1118:1122	PGSST	SPOP	0.981	More...
Q96L96	Alpha-protein kinase 3	DEG_SPOP_SBC_1	77:81	PGSST	SPOP	0.9946	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	660:664	PGSST	SPOP	0.9788	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	DEG_SPOP_SBC_1	454:458	PGSST	SPOP	0.9977	More...
Q9UKD1	Glucocorticoid modulatory element-binding protein 2	DEG_SPOP_SBC_1	495:499	PGSST	SPOP	0.6991	More...
Q9UPT9	Ubiquitin carboxyl-terminal hydrolase 22	DEG_SPOP_SBC_1	332:336	PGSST	SPOP	0.9585	More...
Q9UQC2	GRB2-associated-binding protein 2	DEG_SPOP_SBC_1	457:461	PGSST	SPOP	0.9866	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SPOP_SBC_1	14:18	PGSST	SPOP	0.9967	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	386:390	PGSST	SPOP	0.948	More...
Q9C0E2	Exportin-4	DEG_SPOP_SBC_1	522:526	PGSST	SPOP	0.9799	More...
Q8NDD1	Uncharacterized protein C1orf131	DEG_SPOP_SBC_1	17:21	PGSST	SPOP	0.968	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1572:1576	PGSST	SPOP	0.9337	More...
Q9ULL5	Proline-rich protein 12	DEG_SPOP_SBC_1	137:141	PGSST	SPOP	0.967	More...
Q5T035	Putative uncharacterized protein C9orf129	DEG_SPOP_SBC_1	103:107	PGSST	SPOP	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSST

Degron related mutations and impact score

Drug responses associated with HCN1 mutations

All proteins holding degron of PGSST