DegronMD - P52799(EFNB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H313Y	TCGA-28-1760	GBM	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1111
p.H313Y	DO13725	GBM	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1111
p.G309D	TCGA-2Y-A9H3	LIHC	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.G309D	DO219525	LIHC	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.D297N	TCGA-85-7696	LUSC	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.25
p.D297N	DO26671	LUSC	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.25
p.Y311C	TCGA-A8-A09Z	BRCA	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation blocking phosphorylation signal	0.6111
p.Y311C	DO5521	BRCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation blocking phosphorylation signal	0.6111
p.T196A	TCGA-AG-A002	READ	TCGA	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1111
p.G309S	TCGA-D1-A15X	UCEC	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.G309S	DO43274	UCEC	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.P314Q	TCGA-D3-A2JL	SKCM	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.0833
p.P314Q	DO47278	SKCM	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.0833
p.P204L	TCGA-DD-AAEI	LIHC	TCGA	PGSST	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.7582
p.P204L	DO219575	LIHC	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.7582
p.S194L	TCGA-E6-A1LX	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.S194L	TCGA-EI-6917	READ	TCGA	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.S194L	DO222884	COCA	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.S194L	DO36881	READ	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.S194L	DO41020	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.A213T	TCGA-G4-6317	COAD	TCGA	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.A213T	DO218831	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.A213T	DO10100	COAD	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.V299I	TCGA-WS-AB45	COAD	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.3056
p.V299I	DO51734	COAD	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.3056
p.V299I	DO35083	PACA	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.3056
p.G312R	TCGA-XK-AAIW	PRAD	TCGA	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1389
p.G312R	DO51407	PRAD	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1389
p.P292L	DO234389	ESAD	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1111
p.S308R	DO228948	LICA	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation blocking phosphorylation signal	0.6944
p.S206C	DO232028	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.7541
p.T295N	DO229041	LICA	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1944
p.A296V	DO228138	PBCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.V299A	DO228138	PBCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.3056

Kaplan plot for EFNB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFNB2

UniProt ID: P52799

Entrez ID: 1948

Protein name: Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFNB2 in