DegronMD

Uniprot ID: P52799

Source protein: Ephrin-B2

Source gene: EFNB2

Class: LIG_APCC_ABBA_1

Location: 300:305

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9573

ASA_SCORE: 56.0333

COIL: 0.4962

CONS_SCORE: 0.4494

DSS_SCORE: 0.3341

HELIX: 0.0305

FCONS_SCORE: 0.9704

RIG_SCORE: 0.7928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H313Y	TCGA-28-1760	GBM	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.1111
p.H313Y	DO13725	GBM	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.1111
p.G309D	TCGA-2Y-A9H3	LIHC	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.2222
p.G309D	DO219525	LIHC	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.2222
p.D297N	TCGA-85-7696	LUSC	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.25
p.D297N	DO26671	LUSC	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.25
p.Y311C	TCGA-A8-A09Z	BRCA	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.6111
p.Y311C	DO5521	BRCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.6111
p.G309S	TCGA-D1-A15X	UCEC	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.2222
p.G309S	DO43274	UCEC	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.2222
p.P314Q	TCGA-D3-A2JL	SKCM	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.0833
p.P314Q	DO47278	SKCM	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.0833
p.V299I	TCGA-WS-AB45	COAD	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.3056
p.V299I	DO51734	COAD	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.3056
p.V299I	DO35083	PACA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.3056
p.G312R	TCGA-XK-AAIW	PRAD	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.1389
p.G312R	DO51407	PRAD	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.1389
p.P292L	DO234389	ESAD	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.1111
p.S308R	DO228948	LICA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.6944
p.T295N	DO229041	LICA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.1944
p.A296V	DO228138	PBCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.2222
p.V299A	DO228138	PBCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons