DegronMD

Uniprot ID: Q15768

Source protein: Ephrin-B3

Source gene: EFNB3

Class: LIG_APCC_ABBA_1

Location: 307:312

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 65.0667

COIL: 0.7408

CONS_SCORE: 0.4693

DSS_SCORE: 0.4632

HELIX: 0.1058

FCONS_SCORE: 1.1555

RIG_SCORE: 0.7388

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y311C	SIDM00735	Small Cell Lung Carcinoma	GDSC	FCPHYE	LIG_APCC_ABBA_1	0.7087
p.Y311C	ACH-000298	Lung Cancer	CCLE	FCPHYE	LIG_APCC_ABBA_1	0.7087
p.Y311C	NCI-H2029	lung	COSMIC	FCPHYE	LIG_APCC_ABBA_1	0.7087
p.P306S	DO220903	MELA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.3056
p.P306H	SIDM01318	Hepatocellular Carcinoma	GDSC	FCPHYE	LIG_APCC_ABBA_1	0.3056
p.P305S	DO222644	MELA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.2778
p.S315T	SIDM00980	Gastric Carcinoma	GDSC	FCPHYE	LIG_APCC_ABBA_1	0.25
p.S315T	ACH-000948	Gastric Cancer	CCLE	FCPHYE	LIG_APCC_ABBA_1	0.25
p.S315T	23132-87	stomach	COSMIC	FCPHYE	LIG_APCC_ABBA_1	0.25
p.G301E	TCGA-BF-A1PU	SKCM	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.1667
p.G301E	DO50278	SKCM	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.1667
p.G300D	TCGA-27-2528	GBM	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.1389
p.G300D	DO11782	GBM	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.1389
p.R298Q	TCGA-4Z-AA81	BLCA	TCGA	FCPHYE	LIG_APCC_ABBA_1	0.0833
p.R298Q	DO51868	BLCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons