DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FCPHYE
Uniprot ID:
Q15768
Source protein:
Ephrin-B3
Source gene:
EFNB3
Class:
LIG_APCC_ABBA_1
Location:
307:312
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9987
ASA_SCORE:
65.0667
COIL:
0.7408
CONS_SCORE:
0.4693
DSS_SCORE:
0.4632
HELIX:
0.1058
FCONS_SCORE:
1.1555
RIG_SCORE:
0.7388
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G300D
TCGA-27-2528
GBM
TCGA
FCPHYE
LIG_APCC_ABBA_1
0.1389
p.G300D
DO11782
GBM
ICGC
FCPHYE
LIG_APCC_ABBA_1
0.1389
p.R298Q
TCGA-4Z-AA81
BLCA
TCGA
FCPHYE
LIG_APCC_ABBA_1
0.0833
p.R298Q
DO51868
BLCA
ICGC
FCPHYE
LIG_APCC_ABBA_1
0.0833
p.G301E
TCGA-BF-A1PU
SKCM
TCGA
FCPHYE
LIG_APCC_ABBA_1
0.1667
p.G301E
DO50278
SKCM
ICGC
FCPHYE
LIG_APCC_ABBA_1
0.1667
p.P306S
DO220903
MELA
ICGC
FCPHYE
LIG_APCC_ABBA_1
0.3056
p.P305S
DO222644
MELA
ICGC
FCPHYE
LIG_APCC_ABBA_1
0.2778
p.Y311C
SIDM00735
Small Cell Lung Carcinoma
GDSC
FCPHYE
LIG_APCC_ABBA_1
0.7087
p.Y311C
ACH-000298
Lung Cancer
CCLE
FCPHYE
LIG_APCC_ABBA_1
0.7087
p.Y311C
NCI-H2029
lung
COSMIC
FCPHYE
LIG_APCC_ABBA_1
0.7087
p.S315T
SIDM00980
Gastric Carcinoma
GDSC
FCPHYE
LIG_APCC_ABBA_1
0.25
p.S315T
ACH-000948
Gastric Cancer
CCLE
FCPHYE
LIG_APCC_ABBA_1
0.25
p.S315T
23132-87
stomach
COSMIC
FCPHYE
LIG_APCC_ABBA_1
0.25
p.P306H
SIDM01318
Hepatocellular Carcinoma
GDSC
FCPHYE
LIG_APCC_ABBA_1
0.3056
Drug responses associated with EFNB3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FCPHYE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P52799
Ephrin-B2
LIG_APCC_ABBA_1
300:305
FCPHYE
APC,CDC20,FZR1
0.9573
More...
Q15768
Ephrin-B3
LIG_APCC_ABBA_1
307:312
FCPHYE
APC,CDC20,FZR1
0.9987
More...