DegronMD - Q15768(EFNB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G300D	TCGA-27-2528	GBM	TCGA	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1389
p.G300D	DO11782	GBM	ICGC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1389
p.R298Q	TCGA-4Z-AA81	BLCA	TCGA	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.0833
p.R298Q	DO51868	BLCA	ICGC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.0833
p.P207H	TCGA-95-7039	LUAD	TCGA	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.2222
p.P207H	DO23907	LUAD	ICGC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.2222
p.G301E	TCGA-BF-A1PU	SKCM	TCGA	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1667
p.G301E	DO50278	SKCM	ICGC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1667
p.A193D	TCGA-DM-A1D8	COAD	TCGA	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1667
p.A193D	DO8914	COAD	ICGC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1667
p.N210S	TCGA-GN-A8LK	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1389
p.N210S	DO51259	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1389
p.A192T	DO223505	CLLE	ICGC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1389
p.P306S	DO220903	MELA	ICGC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.3056
p.P305S	DO222644	MELA	ICGC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.2778
p.SR213SW	DO222824	MELA	ICGC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0
p.H194R	DO229234	THCA	ICGC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	SIDM00461	Acute Myeloid Leukemia	GDSC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	SIDM01519	Head and Neck Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	ACH-000786	Lymphoma	CCLE	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	ACH-000992	Head and Neck Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	ACH-001067	Brain Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.T208S	Daudi	haematopoietic and lymphoid tissue	COSMIC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.1944
p.Y311C	SIDM00735	Small Cell Lung Carcinoma	GDSC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.7087
p.Y311C	ACH-000298	Lung Cancer	CCLE	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.7087
p.Y311C	NCI-H2029	lung	COSMIC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.7087
p.S213F	SIDM00685	Glioblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.0556
p.S213F	ACH-000819	Brain Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.0556
p.S213F	LN-18	central nervous system	COSMIC	GKENL	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.0556
p.S315T	SIDM00980	Gastric Carcinoma	GDSC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.25
p.S315T	ACH-000948	Gastric Cancer	CCLE	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.25
p.S315T	23132-87	stomach	COSMIC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.25
p.P306H	SIDM01318	Hepatocellular Carcinoma	GDSC	FCPHYE	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.3056

Kaplan plot for EFNB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFNB3

UniProt ID: Q15768

Entrez ID: 1949

Protein name: Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFNB3 in