DegronMD - P49639(HOXA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S16T	TCGA-24-1104	OV	TCGA	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.25
p.S16T	DO31909	OV	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.25
p.H335Y	TCGA-49-AARE	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.H335Y	DO218922	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.P321H	TCGA-55-7910	LUAD	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.7694
p.P321H	DO23669	LUAD	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.7694
p.T330S	TCGA-78-7147	LUAD	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1389
p.T330S	TCGA-78-7147	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.T330S	DO24527	LUAD	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1389
p.T330S	DO24527	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.T333I	TCGA-A5-A1OF	UCEC	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.0556
p.T333I	TCGA-A5-A1OF	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.T333I	DO42568	UCEC	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.0556
p.T333I	DO42568	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.E312D	TCGA-AJ-A3EL	UCEC	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.2778
p.E312D	DO41542	UCEC	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.2778
p.R26Q	TCGA-AP-A1DR	UCEC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.2778
p.R26Q	DO43747	UCEC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.2778
p.R26Q	SIDM00068	Colorectal Carcinoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.2778
p.R26Q	ACH-002394	Colon/Colorectal Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.2778
p.R26Q	GEO	large intestine	COSMIC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.2778
p.D31N	TCGA-BR-8380	STAD	TCGA	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.1389
p.D31N	DO45299	LIRI	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.1389
p.D31N	DO47803	STAD	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.1389
p.S316Y	TCGA-BS-A0UJ	UCEC	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6009
p.S316Y	DO42745	UCEC	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6009
p.S316Y	SIDM01611	Endometrial Carcinoma	GDSC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6009
p.S316Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6009
p.E308K	TCGA-CV-7102	HNSC	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1667
p.E308K	DO14194	HNSC	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1667
p.T330I	TCGA-DH-A7UR	LGG	TCGA	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1389
p.T330I	TCGA-DH-A7UR	LGG	TCGA	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.T330I	DO51809	LGG	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1389
p.T330I	DO51809	LGG	ICGC	PGSST	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.S30W	TCGA-XF-A9SY	BLCA	TCGA	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation blocking phosphorylation signal	0.6111
p.S30W	DO51918	BLCA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation blocking phosphorylation signal	0.6111
p.S322P	DO227854	BRCA	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6752
p.S16N	DO233941	GACA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.25
p.S322Y	DO229026	LICA	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.712
p.G21R	DO231160	LUSC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation altering degron motif	0.7568
p.E309K	DO220894	MELA	ICGC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.1944
p.S20L	DO49145	PACA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation altering degron motif	0.7667
p.S16G	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.25
p.D304G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.0556
p.D304G	ACH-002256	Leukemia	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.0556
p.D304G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation rewiring degron network	0.0556
p.V320I	SIDM00342	T-Lymphoblastic Leukemia	GDSC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.7076
p.V320I	ACH-000104	Leukemia	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.7076
p.V320I	LOUCY	haematopoietic and lymphoid tissue	COSMIC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.7076
p.F9V	SIDM00239	Kidney Carcinoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.0556
p.F9V	ACH-000159	Kidney Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.0556
p.F9V	OS-RC-2	kidney	COSMIC	DSGTCS	DEG_SCF_TRCP1_1	19:24	Mutation rewiring degron network	0.0556
p.S317L	ACH-000681	Lung Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6556
p.S317L	ACH-001201	Brain Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6556
p.P318H	ACH-000868	Lung Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6583
p.S314P	ACH-000999	Colon/Colorectal Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6752
p.S314P	SNU-1040	large intestine	COSMIC	SSSSPCVPSP	DEG_COP1_1	314:323	Mutation altering degron motif	0.6752

Kaplan plot for HOXA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXA1

UniProt ID: P49639

Entrez ID: 3198

Protein name: Homeobox protein Hox-A1 (Homeobox protein Hox-1F)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXA1 in