DegronMD

Uniprot ID: P49639

Source protein: Homeobox protein Hox-A1

Source gene: HOXA1

Class: DEG_SCF_TRCP1_1

Location: 19:24

E3 ligase: BTRC

DEGRON score: 0.9758

ASA_SCORE: 43.1667

COIL: 0.7517

CONS_SCORE: 0.3948

DSS_SCORE: 0.3042

HELIX: 0.167

FCONS_SCORE: 1.0008

RIG_SCORE: 0.6663

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S20L	DO49145	PACA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.7667
p.G21R	DO231160	LUSC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.7568
p.S30W	TCGA-XF-A9SY	BLCA	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.6111
p.S30W	DO51918	BLCA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.6111
p.R26Q	TCGA-AP-A1DR	UCEC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.2778
p.R26Q	DO43747	UCEC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.2778
p.R26Q	SIDM00068	Colorectal Carcinoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	0.2778
p.R26Q	ACH-002394	Colon/Colorectal Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	0.2778
p.R26Q	GEO	large_intestine	COSMIC	DSGTCS	DEG_SCF_TRCP1_1	0.2778
p.S16T	TCGA-24-1104	OV	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.25
p.S16T	DO31909	OV	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.25
p.S16N	DO233941	GACA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.25
p.S16G	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	0.25
p.D31N	TCGA-BR-8380	STAD	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.D31N	DO45299	LIRI	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.D31N	DO47803	STAD	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.F9V	SIDM00239	Kidney Carcinoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	0.0556
p.F9V	ACH-000159	Kidney Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	0.0556
p.F9V	OS-RC-2	kidney	COSMIC	DSGTCS	DEG_SCF_TRCP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons