DegronMD

Uniprot ID: P35611

Source protein: Alpha-adducin

Source gene: ADD1

Class: DEG_SCF_TRCP1_1

Location: 426:431

E3 ligase: BTRC

DEGRON score: 0.9889

ASA_SCORE: 57.25

COIL: 0.8288

CONS_SCORE: 0.3733

DSS_SCORE: 0.4667

HELIX: 0.1127

FCONS_SCORE: 0.9332

RIG_SCORE: 0.6508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G425C	TCGA-60-2714	LUSC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.3056
p.G425C	TCGA-D3-A2JB	SKCM	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.3056
p.G425C	DO26530	LUSC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.3056
p.G425C	DO47607	SKCM	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.3056
p.Q438H	TCGA-60-2714	LUSC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.Q438H	DO26530	LUSC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.D426N	TCGA-A2-A0SY	BRCA	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.6932
p.D426N	TCGA-Q1-A73P	CESC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.6932
p.D426N	DO2961	BRCA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.6932
p.D426N	DO49983	CESC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.6932
p.S427P	TCGA-B5-A1MX	UCEC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.7863
p.S427P	DO41999	UCEC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.7863
p.P432T	TCGA-EE-A2A5	SKCM	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.3056
p.P432T	DO37941	SKCM	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.3056
p.Q438R	TCGA-YD-A9TA	SKCM	TCGA	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.Q438R	DO219503	SKCM	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.Y419H	DO228017	SKCA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	0.1389
p.S427L	SIDM00148	Breast Carcinoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	0.8778
p.S427L	ACH-000019	Breast Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	0.8778
p.S427L	ACH-000028	Breast Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	0.8778
p.S427L	MCF7	breast	COSMIC	DSGTCS	DEG_SCF_TRCP1_1	0.8778

DegronMD: protein-targeted degradation, mutation and drug response to degrons